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Open AccessArticle

The Predictive Value of Plasma Brain Natriuretic Peptide and Galectin-3 in Elderly Patients Admitted for Heart Failure

Cardiovascular Rehabilitation-Heart Failure Unit Ospedale SS Trinità Fossano, 12045 Fossano, Italy
Emergency 118 ASL CN1 Cuneo, 12100 Cuneo, Italy
School of Geriatry Università degli Studi Torino, 10134 Turin, Italy
Division of Cardiology, Ospedale Regina Montis Regalis, Strada del Rocchetto 99, 12084 Mondovì, Italy
Authors to whom correspondence should be addressed.
This study did not have any financial support.
Diseases 2018, 6(4), 88;
Received: 29 July 2018 / Revised: 11 September 2018 / Accepted: 21 September 2018 / Published: 27 September 2018
(This article belongs to the Section Cardiology)
Galectin-3 is demonstrated to be a robust independent marker of cardiovascular mid-term (18-month) outcomes in heart failure (HF) patients. The aim of this study was to analyze the value of a pre-discharged determination of galectin-3 alone and with brain natriuretic peptide (BNP) in predicting mid-term outcomes in elderly patients (>70 years old) discharged after an acute decompensated HF (ADHF) episode. Methods: all elderly (≥70 years old) HF subjects discharged alive after an ADHF were enrolled. All patients underwent a determination of BNP and galectin-3, a 6-min walking test (6MWT), and an echocardiogram within 48 h of hospital discharge. Cardiac death, cardiac transplantation, and worsening heart failure requiring readmission to hospital were considered cardiovascular events. Results: 84 patients (63 males (75%), age 77.5 ± 5.9 years old) were analyzed (mean follow-up: 16.2 ± 12.3 months). During the follow-up, 45 events (53.6%) were scheduled (18 cardiac deaths, 27 re-hospitalizations for ADHF). HF patients who suffered an event demonstrated more impaired ventricular function (p = 0.04), higher value of BNP (p = 0.02), and Gal-3 at a pre-discharge evaluation (p = 0.05). By choosing adequate cut-off points (BNP ≥ 500 pg/mL and Gal-3 ≥ 17.6 ng/mL), the Kaplan–Meier curves depicted a powerful stratification using Galectin-3 > 17.6 ng/mL alone (log-rank 13.22; p = 0.0003), and by adding BNP + Gal-3, an even better result was obtained (log-rank 17.96; p < 0.00001). Conclusion: in an elderly population, by adding Gal-3 to BNP, a single pre-discharge strategy testing seemed to obtain a satisfactorily predictive value in alive HF patients discharged after an ADHF episode. View Full-Text
Keywords: galectin-3; B type-natriuretic peptide; heart failure; elderly galectin-3; B type-natriuretic peptide; heart failure; elderly
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Testa, M.; Rosso, G.L.; Ferreri, C.; Feola, M. The Predictive Value of Plasma Brain Natriuretic Peptide and Galectin-3 in Elderly Patients Admitted for Heart Failure. Diseases 2018, 6, 88.

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