Liver Damage and Impaired Coagulation in COVID-19 Patients: A Case Series
Abstract
:1. Introduction
2. Materials and Methods
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Patients | #1 | #2 | #3 | #4 | #5 | #6 | #7 | #8 | #9 | #10 |
---|---|---|---|---|---|---|---|---|---|---|
Age | 51 | 52 | 85 | 74 | 77 | 62 | 64 | 71 | 83 | 21 |
Sex | M | M | M | M | F | M | F | M | F | M |
Hospital stay (days) | 9 | 18 | 27 | 12 | 10 | 26 | 7 | 2 | 1 | 1 |
Comorbidities | - | - | HF | PF | - | AH | DM2 | AH | Stroke | - |
Cause of death | PE | PNA | PNA | PE | CVA | PE | DIC | PE | DIC | DIC |
INR | ||||||||||
T0 | 1.06 | 0.96 | 0.89 | 1.22 | 3.57 | 0.91 | 1 | 1.13 | 1.3 | 1.42 |
T1 | 1.03 | 1.17 | 3.03 | 1.33 | 1.28 | 1.77 | 1.13 | 1.2 | 1.37 | 1.45 |
aPTT (s) | ||||||||||
T0 | 31 | 15 | 35 | 39 | 37 | 33 | 35 | 58 | 39 | 31 |
T1 | 115 | 40 | 67 | 39 | 40 | 121 | 40 | 67 | 40 | 35 |
Fibrinogen (mg/dL) | ||||||||||
T0 | 546 | 164 | 368 | 303 | 618 | 603 | 636 | 542 | 448 | 604 |
T1 | 960 | 500 | 220 | 182 | 812 | 585 | 708 | 563 | 453 | 608 |
AT-III (%) | ||||||||||
T0 | 80 | 120 | 85 | 92 | 97 | 106 | 100 | 84 | 95 | 100 |
T1 | 71 | 118 | 110 | 106 | 82 | 73 | 80 | 88 | 97 | 111 |
D-Dimers (μg/L) | ||||||||||
T0 | 0.77 | 15.38 | 0.75 | 0.44 | 5.89 | 0.38 | 0.95 | 1.13 | 1.89 | 0.79 |
T1 | 6.83 | 15.38 | 0.75 | 0.38 | 5.89 | 4.44 | 3.67 | 1.13 | 1.86 | 0.81 |
AST (UI/L) | ||||||||||
T0 | 45 | 27 | 25 | 18 | 15 | 24 | 27 | 27 | 38 | 19 |
T1 | 92 | 63 | 1886 | 87 | 641 | 24 | 30 | 23 | 56 | 13 |
ALT (UI/L) | ||||||||||
T0 | 62 | 62 | 12 | 19 | 19 | 19 | 38 | 51 | 54 | 12 |
T1 | 52 | 36 | 162 | 23 | 469 | 18 | 40 | 53 | 50 | 25 |
GGT (UI/L) | ||||||||||
T0 | 21 | 68 | 21 | 28 | 69 | 38 | 53 | 91 | 34 | 30 |
T1 | 39 | 271 | 96 | 14 | 151 | 13 | 58 | 73 | 47 | 45 |
ALP (UI/L) | ||||||||||
T0 | 46 | 74 | 80 | 84 | 62 | 63 | 67 | 42 | 81 | 75 |
T1 | 180 | 261 | 103 | 55 | 128 | 72 | 105 | 30 | 101 | 100 |
Albumin (g/dL) | ||||||||||
T0 | 3.2 | 3.3 | 3.7 | 3.2 | 3.0 | 3.9 | 3.5 | 3.4 | 3.8 | 3.1 |
T1 | 2 | 2.6 | 3.5 | 3.1 | 3.2 | 2.9 | 3.2 | 2.8 | 2.4 | 2.4 |
T0 | T1 | p-Value | |
---|---|---|---|
INR | 1.35 ± 0.8 | 1.48 ± 0.58 | 0.114 |
aPTT (s) | 35.3 ± 10.54 | 60.4 ± 32.5 | 0.009 |
Fibrinogen (mg/dL) | 438.2 ± 158.72 | 559.1 ± 240.8 | 0.226 |
AT-III (%) | 95.88 ± 11.76 | 85.27 ± 32.01 | 0.689 |
D-Dimers (μg/L) | 2.84 ± 4.7 | 4.13 ± 4.57 | 0.052 |
AST (UI/L) | 26.5 ± 9.1 | 291.5 ± 590.1 | 0.17 |
ALT (UI/L) | 34.8 ± 20.9 | 92.8 ± 138.4 | 0.20 |
GGT (UI/L) | 45.7 ± 23.7 | 80.7 ± 78.3 | 0.19 |
ALP (UI/L) | 67.5 ± 14.5 | 113.5 ± 65.9 | 0.044 |
Albumin (g/dL) | 3.41 ± 0.3 | 2.71 ± 0.5 | 0.0009 |
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Abenavoli, L.; Aquila, I.; Sacco, M.A.; Scarlata, G.G.M.; Procopio, A.C.; Boccuto, L.; Scarpellini, E.; Greco, M.; Foti, D.P.; Ricci, P.; et al. Liver Damage and Impaired Coagulation in COVID-19 Patients: A Case Series. Diseases 2023, 11, 141. https://doi.org/10.3390/diseases11040141
Abenavoli L, Aquila I, Sacco MA, Scarlata GGM, Procopio AC, Boccuto L, Scarpellini E, Greco M, Foti DP, Ricci P, et al. Liver Damage and Impaired Coagulation in COVID-19 Patients: A Case Series. Diseases. 2023; 11(4):141. https://doi.org/10.3390/diseases11040141
Chicago/Turabian StyleAbenavoli, Ludovico, Isabella Aquila, Matteo Antonio Sacco, Giuseppe Guido Maria Scarlata, Anna Caterina Procopio, Luigi Boccuto, Emidio Scarpellini, Marta Greco, Daniela Patrizia Foti, Pietrantonio Ricci, and et al. 2023. "Liver Damage and Impaired Coagulation in COVID-19 Patients: A Case Series" Diseases 11, no. 4: 141. https://doi.org/10.3390/diseases11040141
APA StyleAbenavoli, L., Aquila, I., Sacco, M. A., Scarlata, G. G. M., Procopio, A. C., Boccuto, L., Scarpellini, E., Greco, M., Foti, D. P., Ricci, P., & Luzza, F. (2023). Liver Damage and Impaired Coagulation in COVID-19 Patients: A Case Series. Diseases, 11(4), 141. https://doi.org/10.3390/diseases11040141