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Article

The Ethanol Extract of Musa sapientum Linn. Peel Inhibits Melanogenesis through AKT Signaling Pathway

1
Biopharmaceutical Sciences Program, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand
2
Department of Microbiology, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand
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Department of Biochemistry, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand
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Department of Pharmacology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand
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Department of Biological Science, National Sun Yat-sen University, Kaohsiung 80424, Taiwan
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Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 40402, Taiwan
*
Authors to whom correspondence should be addressed.
Academic Editors: Vasil Georgiev, Christophe Hano and Duangjai Tungmunnithum
Cosmetics 2021, 8(3), 70; https://doi.org/10.3390/cosmetics8030070
Received: 17 July 2021 / Revised: 2 August 2021 / Accepted: 3 August 2021 / Published: 5 August 2021
(This article belongs to the Special Issue Cosmetics in the Age of Green Technologies)
Hyperpigmentation caused by melanin overproduction can be induced by UV radiation. The quest for effective depigmenting agents continues because many anti-melanin agents have restricted use and/or produce side-effects. The present study was aimed to investigate the inhibitory activity of Musa sapientum Linn. (AA group) peel ethanol extracts (MPE) on α-melanocyte stimulating hormone (α-MSH)-induced melanin production. In addition, the molecular mechanism related to this process was examined in B16F10 mouse melanoma cells. The results indicated that MPE remarkably inhibited melanogenesis in α-MSH-stimulated B16F10 cells. Microphthalmia-associated transcription factor (MITF) and tyrosinase expressions were suppressed by MPE in a concentration-dependent manner. In addition, MPE significantly decreased the expression of melanosome transfer protein markers (Rab27a and Pmel17) in a dose-dependent manner. This study found that the elevated phosphorylation of AKT in the B16F10 cells was diminished by MPE treatment. Furthermore, microtubule-associated protein 1 light chain 3 (LC3)-II and p62 (autophagy markers) were affected after the B16F10 cells were treated with MPE. This study demonstrated that MPE might be an effective agent for anti-melanogenesis through the AKT pathway, subsequently diminishing MITF expression and tyrosinase enzyme family production. The findings indicated that MPE could potentially serve as a depigmenting agent in cosmeceuticals. View Full-Text
Keywords: phenolic compounds; banana; cell signaling pathway; melanogenesis; melanin phenolic compounds; banana; cell signaling pathway; melanogenesis; melanin
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MDPI and ACS Style

Phacharapiyangkul, N.; Thirapanmethee, K.; Sa-ngiamsuntorn, K.; Panich, U.; Lee, C.-H.; Chomnawang, M.T. The Ethanol Extract of Musa sapientum Linn. Peel Inhibits Melanogenesis through AKT Signaling Pathway. Cosmetics 2021, 8, 70. https://doi.org/10.3390/cosmetics8030070

AMA Style

Phacharapiyangkul N, Thirapanmethee K, Sa-ngiamsuntorn K, Panich U, Lee C-H, Chomnawang MT. The Ethanol Extract of Musa sapientum Linn. Peel Inhibits Melanogenesis through AKT Signaling Pathway. Cosmetics. 2021; 8(3):70. https://doi.org/10.3390/cosmetics8030070

Chicago/Turabian Style

Phacharapiyangkul, Naphichaya, Krit Thirapanmethee, Khanit Sa-ngiamsuntorn, Uraiwan Panich, Che-Hsin Lee, and Mullika T. Chomnawang. 2021. "The Ethanol Extract of Musa sapientum Linn. Peel Inhibits Melanogenesis through AKT Signaling Pathway" Cosmetics 8, no. 3: 70. https://doi.org/10.3390/cosmetics8030070

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