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Article

Treatment of Head Louse Infestation with a Novel Mixture Made of Semi-Crystalline Polymers and Plant Extracts: Blind, Randomized, Controlled, Superiority Trial

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Department of Physiology and Pharmacology, State University of Ceará, Avenue Paranjana 1700, Fortaleza 60740-000, Brazil
2
Laboratory of Electrophysiology, Superior Institute of Biomedical Sciences, State University of Ceará, Avenue Paranjana, 1700 Campus of Itaperi, Fortaleza 60740-903, Brazil
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Veterinary Faculty, State University of Ceará, Avenue Paranjana 1700, Fortaleza 60740-000, Brazil
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Faculty of Medicine of the State University of Ceará, Avenue Paranjana 1700, Fortaleza 60740-000, Brazil
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Univ. Lille, CHU Lille, ULR2694 (METRICS: évaluation des technologies de santé et des pratiques médicales), F-59000 Lille, France
*
Author to whom correspondence should be addressed.
Cosmetics 2020, 7(2), 25; https://doi.org/10.3390/cosmetics7020025
Received: 6 March 2020 / Revised: 1 April 2020 / Accepted: 3 April 2020 / Published: 10 April 2020
The rate of head louse infestations is increasing. Most of the neurotoxic treatments are not reliably ovicidal and are faced with genetic resistance. The treatments based on a mechanical mode of action show no sufficient efficacy, transferring the chances of a cure on a tedious combing or leaving the hair fatty. This double-blinded, randomized, controlled, superiority trial evaluates the efficacy and safety of a novel mixture made of semi-crystalline polymers and plant extracts. Forty-five participants received a single application of either 1% Permethrin lotion or the novel lotion, applied for 15 minutes. Untreated and treated nits were collected and placed in an incubator during 10 days. The worst case intent-to-treat analysis found the novel lotion significantly more effective than 1% Permethrin, with 21/22 (95.5%) participants cured and 9/23 (39.1%), respectively (p < 0.0001). Rate of viable nymphs was 0.5 (2.1) for the new lotion and 40.8 (20.4) for the 1% Permethrin. The new lotion cures head louse infestations, offering an effective alternative treatment, with a high efficacy for inhibiting the hatching of eggs. Its physical actions on lice and their eggs should not be affected by resistance to neurotoxic insecticides. View Full-Text
Keywords: head lice; treatment; shampoo; Pediculus humanus capitis; clinical trial; clinical study; randomized; blinded; controlled head lice; treatment; shampoo; Pediculus humanus capitis; clinical trial; clinical study; randomized; blinded; controlled
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MDPI and ACS Style

Leal Cardoso, J.H.; Noronha Coelho de Souza, A.; Militão de Souza, F.; Sa Preire, S.; Pinçon, C. Treatment of Head Louse Infestation with a Novel Mixture Made of Semi-Crystalline Polymers and Plant Extracts: Blind, Randomized, Controlled, Superiority Trial. Cosmetics 2020, 7, 25. https://doi.org/10.3390/cosmetics7020025

AMA Style

Leal Cardoso JH, Noronha Coelho de Souza A, Militão de Souza F, Sa Preire S, Pinçon C. Treatment of Head Louse Infestation with a Novel Mixture Made of Semi-Crystalline Polymers and Plant Extracts: Blind, Randomized, Controlled, Superiority Trial. Cosmetics. 2020; 7(2):25. https://doi.org/10.3390/cosmetics7020025

Chicago/Turabian Style

Leal Cardoso, José H., Andrelina Noronha Coelho de Souza, Francisco Militão de Souza, Samia Sa Preire, and Claire Pinçon. 2020. "Treatment of Head Louse Infestation with a Novel Mixture Made of Semi-Crystalline Polymers and Plant Extracts: Blind, Randomized, Controlled, Superiority Trial" Cosmetics 7, no. 2: 25. https://doi.org/10.3390/cosmetics7020025

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