Next Article in Journal
Enigmatic Microalgae from Aeroterrestrial and Extreme Habitats in Cosmetics: The Potential of the Untapped Natural Sources
Next Article in Special Issue
Anti-Wrinkle Efficacy of Neuropeptide Substance P-Based Hydrogel in Human Volunteers
Previous Article in Journal
Physicochemical Aspects of the Performance of Hair-Conditioning Formulations
Previous Article in Special Issue
Development of an Innovative and Eco-Friendly UV Radiation Absorber, Based on Furan Moieties
Open AccessArticle

Treatment of Head Louse Infestation with a Novel Mixture Made of Semi-Crystalline Polymers and Plant Extracts: Blind, Randomized, Controlled, Superiority Trial

1
Department of Physiology and Pharmacology, State University of Ceará, Avenue Paranjana 1700, Fortaleza 60740-000, Brazil
2
Laboratory of Electrophysiology, Superior Institute of Biomedical Sciences, State University of Ceará, Avenue Paranjana, 1700 Campus of Itaperi, Fortaleza 60740-903, Brazil
3
Veterinary Faculty, State University of Ceará, Avenue Paranjana 1700, Fortaleza 60740-000, Brazil
4
Faculty of Medicine of the State University of Ceará, Avenue Paranjana 1700, Fortaleza 60740-000, Brazil
5
Univ. Lille, CHU Lille, ULR2694 (METRICS: évaluation des technologies de santé et des pratiques médicales), F-59000 Lille, France
*
Author to whom correspondence should be addressed.
Cosmetics 2020, 7(2), 25; https://doi.org/10.3390/cosmetics7020025
Received: 6 March 2020 / Revised: 1 April 2020 / Accepted: 3 April 2020 / Published: 10 April 2020
The rate of head louse infestations is increasing. Most of the neurotoxic treatments are not reliably ovicidal and are faced with genetic resistance. The treatments based on a mechanical mode of action show no sufficient efficacy, transferring the chances of a cure on a tedious combing or leaving the hair fatty. This double-blinded, randomized, controlled, superiority trial evaluates the efficacy and safety of a novel mixture made of semi-crystalline polymers and plant extracts. Forty-five participants received a single application of either 1% Permethrin lotion or the novel lotion, applied for 15 minutes. Untreated and treated nits were collected and placed in an incubator during 10 days. The worst case intent-to-treat analysis found the novel lotion significantly more effective than 1% Permethrin, with 21/22 (95.5%) participants cured and 9/23 (39.1%), respectively (p < 0.0001). Rate of viable nymphs was 0.5 (2.1) for the new lotion and 40.8 (20.4) for the 1% Permethrin. The new lotion cures head louse infestations, offering an effective alternative treatment, with a high efficacy for inhibiting the hatching of eggs. Its physical actions on lice and their eggs should not be affected by resistance to neurotoxic insecticides. View Full-Text
Keywords: head lice; treatment; shampoo; Pediculus humanus capitis; clinical trial; clinical study; randomized; blinded; controlled head lice; treatment; shampoo; Pediculus humanus capitis; clinical trial; clinical study; randomized; blinded; controlled
Show Figures

Figure 1

MDPI and ACS Style

Leal Cardoso, J.H.; Noronha Coelho de Souza, A.; Militão de Souza, F.; Sa Preire, S.; Pinçon, C. Treatment of Head Louse Infestation with a Novel Mixture Made of Semi-Crystalline Polymers and Plant Extracts: Blind, Randomized, Controlled, Superiority Trial. Cosmetics 2020, 7, 25.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop