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Novel Synthetic Compounds and Natural Products for Pharmaceutical, Personal Care...
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Novel Synthetic Compounds and Natural Products for Pharmaceutical, Personal Care and Cosmetic: Analytical aspects, Structure Elucidation, Bioactivities and Formulation

A special issue of Cosmetics (ISSN 2079-9284).

Deadline for manuscript submissions: closed (28 February 2020) | Viewed by 24041

Special Issue Editor

Dr. Alessandro Venditti

E-Mail Website
Guest Editor
Department of Chemistry, Universita degli Studi di Roma La Sapienza, Rome, Italy
Interests: organic natural products; extraction and isolation from complex matrices and their molecular structure recognition through application of advanced nuclear magnetic resonance techniques
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The cosmetic chemistry is in continuous development and every day new compounds, either specifically designed synthetic chemicals or Natural Products, reveal interesting properties for application in cosmetic production with different and specialized functions. There is an increasing interest of the cosmetic industry in the development of novel products with functional ingredients (for bioactivities but also for product stability). In this context both synthetic chemistry and Natural Products offer a wide plethora of compounds with different physico-chemical characteristic and possible applications.

This Special Issue "Novel Synthetic Compounds and Natural Products for Pharmaceutical, Personal Care and Cosmetic: Analytical aspects, Structure Elucidation, Bioactivities and Formulation." wants to be a platform to present the utilization in cosmetic products of newly described compounds, either natural products and of synthetic origin. The overview of the current knowledge about their structural description, analytical aspects, bioactivities and technological functions may be provided through original papers, reviews and short communications.

Dr. Venditti Alessandro
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cosmetics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cosmeceutics
  • newly designed compounds
  • natural products
  • functional/active components
  • olfactory research
  • analytical chemistry
  • formulation
  • stability study of emulsions and dispersed systems
  • biologically active components

Published Papers (4 papers)

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Research

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18 pages, 3384 KiB  
Article
Treatment of Head Louse Infestation with a Novel Mixture Made of Semi-Crystalline Polymers and Plant Extracts: Blind, Randomized, Controlled, Superiority Trial
by José Henrique Leal Cardoso, Andrelina Noronha Coelho de Souza, Francisco Militão de Souza, Samia Sa Preire and Claire Pinçon
Cosmetics 2020, 7(2), 25; https://doi.org/10.3390/cosmetics7020025 - 10 Apr 2020
Cited by 2 | Viewed by 5922
Abstract
The rate of head louse infestations is increasing. Most of the neurotoxic treatments are not reliably ovicidal and are faced with genetic resistance. The treatments based on a mechanical mode of action show no sufficient efficacy, transferring the chances of a cure on [...] Read more.
The rate of head louse infestations is increasing. Most of the neurotoxic treatments are not reliably ovicidal and are faced with genetic resistance. The treatments based on a mechanical mode of action show no sufficient efficacy, transferring the chances of a cure on a tedious combing or leaving the hair fatty. This double-blinded, randomized, controlled, superiority trial evaluates the efficacy and safety of a novel mixture made of semi-crystalline polymers and plant extracts. Forty-five participants received a single application of either 1% Permethrin lotion or the novel lotion, applied for 15 minutes. Untreated and treated nits were collected and placed in an incubator during 10 days. The worst case intent-to-treat analysis found the novel lotion significantly more effective than 1% Permethrin, with 21/22 (95.5%) participants cured and 9/23 (39.1%), respectively (p < 0.0001). Rate of viable nymphs was 0.5 (2.1) for the new lotion and 40.8 (20.4) for the 1% Permethrin. The new lotion cures head louse infestations, offering an effective alternative treatment, with a high efficacy for inhibiting the hatching of eggs. Its physical actions on lice and their eggs should not be affected by resistance to neurotoxic insecticides. Full article
(This article belongs to the Special Issue Novel Synthetic Compounds and Natural Products for Pharmaceutical, Personal Care and Cosmetic: Analytical aspects, Structure Elucidation, Bioactivities and Formulation)
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13 pages, 3052 KiB  
Article
Development of an Innovative and Eco-Friendly UV Radiation Absorber, Based on Furan Moieties
by Busalacchi Giacomo, Beverina Luca, Lionetti Nicola and Rigano Luigi
Cosmetics 2020, 7(1), 6; https://doi.org/10.3390/cosmetics7010006 - 8 Jan 2020
Cited by 3 | Viewed by 6654
Abstract
The increasing concern about the environmental impact of ingredients largely used as sunscreens today is pushing research towards new frontiers for the synthesis and degradation potential of innovative sun protection structures. This study deals with the design, synthesis, efficacy evaluation, and environmental impact [...] Read more.
The increasing concern about the environmental impact of ingredients largely used as sunscreens today is pushing research towards new frontiers for the synthesis and degradation potential of innovative sun protection structures. This study deals with the design, synthesis, efficacy evaluation, and environmental impact of new photo-stable molecules at extended electronic conjugation and which have the ‘charge-transfer’ type of optical transition (push and pull). They efficiently perform absorption of electro-magnetic radiation in the UVB and UVA regions. A preliminary screening, dealing with a whole series of aromatic donors, led to the selection of a key substrate derived from waste material, provided with low environmental impact and largely available on the market. As far as the acceptor was concerned, an ester with cyan-acrylic structure and functionalized with aliphatic chains emerged as the most suitable. This allowed a shift of the λ of absorption in the range of the ultraviolet wavelengths. The synthesis procedures include an acid-catalyst-fitted esterification, condensation, and cold crystallization. It was continuously monitored with suitable characterization instruments (GC-MS, 1H NMR, 13C NMR), in order to avoid by-products and parasitic reactions. The resulting structures (patent pending) are composed by a furan core condensed with cyano-acrylic esters, derivatized with branched chains of hydrocarbons of medium length. The obtained structures are capable of good absorption in the range of wavelengths between 300 and 400 nm. Because of their structures, the new molecules are largely soluble in many common oils and cosmetic ingredients. The new molecules have been successively evaluated in terms of photo-stability, biodegradability, compatibility, and UVB-UVA protection capability, both in-vivo and in-vitro, in comparison with existing sunscreens. Full article
(This article belongs to the Special Issue Novel Synthetic Compounds and Natural Products for Pharmaceutical, Personal Care and Cosmetic: Analytical aspects, Structure Elucidation, Bioactivities and Formulation)
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15 pages, 1528 KiB  
Article
Glycerolipid Composition and Advanced Physicochemical Considerations of Sacha Inchi Oil toward Cosmetic Products Formulation
by Diana Penagos-Calvete, Valeria Duque, Claudia Marimon, Diana M. Parra, Sandra K. Restrepo-Arango, Oliver Scherf-Clavel, Ulrike Holzgrabe, Guillermo Montoya and Constain H. Salamanca
Cosmetics 2019, 6(4), 70; https://doi.org/10.3390/cosmetics6040070 - 9 Dec 2019
Cited by 9 | Viewed by 6954
Abstract
Sacha inchi oil is a premier raw material with highly nutritional and functional features for the foodstuff, pharmaceutical, beauty, and personal care industries. One of the most important facts about this oil is the huge chemical content of unsaturated and polyunsaturated fatty acids. [...] Read more.
Sacha inchi oil is a premier raw material with highly nutritional and functional features for the foodstuff, pharmaceutical, beauty, and personal care industries. One of the most important facts about this oil is the huge chemical content of unsaturated and polyunsaturated fatty acids. However, the current available information on the characterization of the triglyceride composition and the advance physicochemical parameters relevant to emulsion development is limited. Therefore, this research focused on providing a detailed description of the lipid composition using high-resolution tandem mass spectrometry and thorough physicochemical characterization to find the value of the required hydrophilic–lipophilic balance (HLB). For this, a study in the interfacial tension was evaluated, followed by the assessment of different parameters such as creaming index, droplet size, viscosity, zeta potential, pH, and electrical conductivity for a series emulsified at thermal stress condition. The results show that fatty acids are arranged into glycerolipids and the required HLB to achieve the maximum physical stability is around 8. Full article
(This article belongs to the Special Issue Novel Synthetic Compounds and Natural Products for Pharmaceutical, Personal Care and Cosmetic: Analytical aspects, Structure Elucidation, Bioactivities and Formulation)
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4 pages, 546 KiB  
Letter
Anti-Wrinkle Efficacy of Neuropeptide Substance P-Based Hydrogel in Human Volunteers
by Da Jung Kim, Seul Bi Lee, Song Sun Chang and Jungsun Lee
Cosmetics 2020, 7(2), 37; https://doi.org/10.3390/cosmetics7020037 - 21 May 2020
Cited by 1 | Viewed by 4081
Abstract
This letter is intended to clarify the clinical effectiveness of neuropeptide substance P (SP) in reducing age-related skin wrinkling. This is the first clinical study to evaluate the efficacy of the topical application of SP on wrinkle reduction. For the clinical study, we [...] Read more.
This letter is intended to clarify the clinical effectiveness of neuropeptide substance P (SP) in reducing age-related skin wrinkling. This is the first clinical study to evaluate the efficacy of the topical application of SP on wrinkle reduction. For the clinical study, we tested the efficacy of a stable SP formulation known as SP-based hydrogel against skin aging in study participants. We found that this SP-based hydrogel reduced skin aging based on changes observed in several cutaneous parameters. Full article
(This article belongs to the Special Issue Novel Synthetic Compounds and Natural Products for Pharmaceutical, Personal Care and Cosmetic: Analytical aspects, Structure Elucidation, Bioactivities and Formulation)
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