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The Role of Mitochondria in Cardiovascular Diseases

1
Department of Basic Research, Institute for Atherosclerosis Research, Skolkovo Innovative Center, 121609 Moscow, Russia
2
Laboratory of Medical Genetics, National Medical Research Center of Cardiology, 15A 3-rd Cherepkovskaya Street, 121552 Moscow, Russia
3
Laboratory of Cellular and Molecular Pathology of Cardiovascular System & Central Laboratory of Pathology, Institute of Human Morphology, 3 Tsyurupa Street, 117418 Moscow, Russia
4
Institute of Cellular and System Medicine, National Health Research Institutes, 35 Keyan Road, Zhunan Town, Miaoli County 35053, Taiwan
5
Laboratory of Infection Pathology and Molecular Microecology, Institute of Human Morphology, 3 Tsyurupa Street, 117418 Moscow, Russia
6
Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, 8 Baltiyskaya st., 125315 Moscow, Russia
*
Author to whom correspondence should be addressed.
Biology 2020, 9(6), 137; https://doi.org/10.3390/biology9060137
Received: 25 May 2020 / Revised: 22 June 2020 / Accepted: 23 June 2020 / Published: 25 June 2020
(This article belongs to the Section Cell Biology)
The role of mitochondria in cardiovascular diseases is receiving ever growing attention. As a central player in the regulation of cellular metabolism and a powerful controller of cellular fate, mitochondria appear to comprise an interesting potential therapeutic target. With the development of DNA sequencing methods, mutations in mitochondrial DNA (mtDNA) became a subject of intensive study, since many directly lead to mitochondrial dysfunction, oxidative stress, deficient energy production and, as a result, cell dysfunction and death. Many mtDNA mutations were found to be associated with chronic human diseases, including cardiovascular disorders. In particular, 17 mtDNA mutations were reported to be associated with ischemic heart disease in humans. In this review, we discuss the involvement of mitochondrial dysfunction in the pathogenesis of atherosclerosis and describe the mtDNA mutations identified so far that are associated with atherosclerosis and its risk factors. View Full-Text
Keywords: atherosclerosis; mitochondria; mitochondrial genome; cardiovascular disease atherosclerosis; mitochondria; mitochondrial genome; cardiovascular disease
MDPI and ACS Style

Poznyak, A.V.; Ivanova, E.A.; Sobenin, I.A.; Yet, S.-F.; Orekhov, A.N. The Role of Mitochondria in Cardiovascular Diseases. Biology 2020, 9, 137.

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