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T Cells in Fish
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Neutrophil Development, Migration, and Function in Teleost Fish

1
Department of Biological Sciences, University of Alberta, Edmonton, AB T6G2P5, Canada
2
Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB T6G2P5, Canada
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Author to whom correspondence should be addressed.
Academic Editor: Brian Dixon
Biology 2015, 4(4), 715-734; https://doi.org/10.3390/biology4040715
Received: 28 September 2015 / Revised: 30 October 2015 / Accepted: 30 October 2015 / Published: 6 November 2015
(This article belongs to the Special Issue Current Understanding of Fish Immune Systems)
It is now widely recognized that neutrophils are sophisticated cells that are critical to host defense and the maintenance of homeostasis. In addition, concepts such as neutrophil plasticity are helping to define the range of phenotypic profiles available to cells in this group and the physiological conditions that contribute to their differentiation. Herein, we discuss key features of the life of a teleost neutrophil including their development, migration to an inflammatory site, and contributions to pathogen killing and the control of acute inflammation. The potent anti-microbial mechanisms elicited by these cells in bony fish are a testament to their long-standing evolutionary contributions in host defense. In addition, recent insights into their active roles in the control of inflammation prior to induction of apoptosis highlight their importance to the maintenance of host integrity in these early vertebrates. Overall, our goal is to summarize recent progress in our understanding of this cell type in teleost fish, and to provide evolutionary context for the contributions of this hematopoietic lineage in host defense and an efficient return to homeostasis following injury or infection. View Full-Text
Keywords: neutrophils; teleost fish; inflammation; innate immunity; comparative immunology; inflammatory resolution neutrophils; teleost fish; inflammation; innate immunity; comparative immunology; inflammatory resolution
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Havixbeck, J.J.; Barreda, D.R. Neutrophil Development, Migration, and Function in Teleost Fish. Biology 2015, 4, 715-734.

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