Biology 2013, 2(3), 976-1033; doi:10.3390/biology2030976
Review

The Role of Nuclear Bodies in Gene Expression and Disease

Department of Medical Genetics, Child & Family Research Institute, University of British Columbia, Vancouver, BC V5Z 4H4, Canada
* Author to whom correspondence should be addressed.
Received: 15 May 2013; in revised form: 13 June 2013 / Accepted: 20 June 2013 / Published: 9 July 2013
(This article belongs to the Special Issue Gene Expression and Regulation)
PDF Full-text Download PDF Full-Text [574 KB, uploaded 9 July 2013 14:08 CEST]
Abstract: This review summarizes the current understanding of the role of nuclear bodies in regulating gene expression. The compartmentalization of cellular processes, such as ribosome biogenesis, RNA processing, cellular response to stress, transcription, modification and assembly of spliceosomal snRNPs, histone gene synthesis and nuclear RNA retention, has significant implications for gene regulation. These functional nuclear domains include the nucleolus, nuclear speckle, nuclear stress body, transcription factory, Cajal body, Gemini of Cajal body, histone locus body and paraspeckle. We herein review the roles of nuclear bodies in regulating gene expression and their relation to human health and disease.
Keywords: nuclear bodies; transcription; gene expression; genome organization

Article Statistics

Load and display the download statistics.

Citations to this Article

Cite This Article

MDPI and ACS Style

Morimoto, M.; Boerkoel, C.F. The Role of Nuclear Bodies in Gene Expression and Disease. Biology 2013, 2, 976-1033.

AMA Style

Morimoto M, Boerkoel CF. The Role of Nuclear Bodies in Gene Expression and Disease. Biology. 2013; 2(3):976-1033.

Chicago/Turabian Style

Morimoto, Marie; Boerkoel, Cornelius F. 2013. "The Role of Nuclear Bodies in Gene Expression and Disease." Biology 2, no. 3: 976-1033.

Biology EISSN 2079-7737 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert