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Nitrogen and Bromide Co-Doped Hydroxyapatite Thin Films with Antimicrobial Properties

National Institute of Materials Physics, Atomistilor Street, No. 405A, P.O. Box MG 07, 077125 Magurele, Romania
Department of Civil Engineering and Environment, Université d’Orléans, ISTO, UMR 7327 CNRS, 1A Rue de la Férollerie, 45071 Orléans, France
Faculty of Horticulture, University of Agronomic Sciences and Veterinary Medicine, 59 Marasti Blvd., 011464 Bucharest, Romania
Department of Mechanics, University Politehnica of Bucharest, BN 002, 313 Splaiul Independentei, Sector 6, 060042 Bucharest, Romania
Life, Environmental and Earth Sciences Division, Research Institute of the University of Bucharest (ICUB), University of Bucharest, 060023 Bucharest, Romania
Microbiology Department, Faculty of Biology, University of Bucharest, 1–3 Portocalelor Lane, 77206 Bucharest, Romania
Academy of Romanian Scientists, 54 Spl. Independentei St., District 5, 50085 Bucharest, Romania
Biological Sciences Division, The Romanian Academy, 25, Calea Victoriei, Sector 1, District 1, 010071 Bucharest, Romania
Authors to whom correspondence should be addressed.
Academic Editor: Enrico Sassoni
Coatings 2021, 11(12), 1505;
Received: 7 November 2021 / Revised: 22 November 2021 / Accepted: 30 November 2021 / Published: 7 December 2021
(This article belongs to the Special Issue Biomaterials and Antimicrobial Coatings)
Hydroxyapatite (Ca10(PO4)6(OH)2, HAp), due to its high biocompatibility, is widely used as biomaterial. Doping with various ions of hydroxyapatite is performed to acquire properties as close as possible to the biological apatite present in bones and teeth. In this research the results of a study performed on thin films of hydroxyapatite co-doped with nitrogen and bromine (NBrHAp) are presented for the first time. The NBrHAp suspension was obtained by performing the adapted co-precipitation method using cetyltrimethylammonium bromide (CTAB). The thin layers of NBrHAp were obtained by spin-coating. The stability of the NBrHAp suspension was examined by ultrasound measurements. The thin layers obtained by the spin-coating method were examined by scanning electron microscopy (SEM), optical microscopy (OM), and metallographic microscopy (MM). The presence of nitrogen and bromine were highlighted by energy-dispersive X-ray spectroscopy (EDS) and X-ray photoelectron spectroscopy (XPS) studies. Fourier transform infrared spectroscopy (FTIR) was used to highlight the chemical status of nitrogen and bromine. In addition, the powder obtained from the NBrHAp suspension was analyzed by XRD. Moreover, the in vitro antimicrobial activity of the NBrHAp suspensions and coatings was investigated using the reference microbial strains Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, and Candida albicans ATCC 10231. The results highlighted the successful obtainment of N and Br co-doped hydroxyapatite suspension for the first time by an adapted co-precipitation method. The obtained suspension was used to produce pure NBrHAp composite thin films with superior morphological properties. The NBrHAp suspensions and coatings exhibited in vitro antimicrobial activity against bacterial and fungal strains and revealed their good antimicrobial activity. View Full-Text
Keywords: nitrogen; bromide; hydroxyapatite; co-doped; thin film; antimicrobial properties nitrogen; bromide; hydroxyapatite; co-doped; thin film; antimicrobial properties
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MDPI and ACS Style

Iconaru, S.L.; Ciobanu, C.S.; Predoi, D.; Motelica-Heino, M.; Negrilă, C.C.; Badea, M.L.; Predoi, M.V.; Chifiriuc, C.M.; Popa, M. Nitrogen and Bromide Co-Doped Hydroxyapatite Thin Films with Antimicrobial Properties. Coatings 2021, 11, 1505.

AMA Style

Iconaru SL, Ciobanu CS, Predoi D, Motelica-Heino M, Negrilă CC, Badea ML, Predoi MV, Chifiriuc CM, Popa M. Nitrogen and Bromide Co-Doped Hydroxyapatite Thin Films with Antimicrobial Properties. Coatings. 2021; 11(12):1505.

Chicago/Turabian Style

Iconaru, Simona Liliana, Carmen Steluta Ciobanu, Daniela Predoi, Mikael Motelica-Heino, Constantin Cătălin Negrilă, Monica Luminita Badea, Mihai Valentin Predoi, Carmen Mariana Chifiriuc, and Marcela Popa. 2021. "Nitrogen and Bromide Co-Doped Hydroxyapatite Thin Films with Antimicrobial Properties" Coatings 11, no. 12: 1505.

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