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Coatings
Volume 10
Issue 8
10.3390/coatings10080715
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Article

Electrodeposition of Hydroxyapatite on a Metallic 3D-Woven Bioscaffold

by
Ju Xue
1,*,
Ashley Farris
2,
Yunfei Wang
1,
Weiyan Yeh
1,
Cristina Romany
1,
James K. Guest
3,4,
Warren L. Grayson
2,
Anthony S. Hall
1 and
Timothy P. Weihs
1,4,*
1
Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD 21218, USA
2
Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA
3
Department of Civil and Systems Engineering, Johns Hopkins University, Baltimore, MD 21218, USA
4
Hopkins Extreme Materials Institute, Johns Hopkins University, Baltimore, MD 21218, USA
*
Authors to whom correspondence should be addressed.
Coatings 2020, 10(8), 715; https://doi.org/10.3390/coatings10080715
Received: 11 May 2020 / Revised: 1 July 2020 / Accepted: 18 July 2020 / Published: 23 July 2020
(This article belongs to the Special Issue Functional Surfaces for Biomedical Applications)
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Abstract

In this study, we demonstrate that a uniform coating of hydroxyapatite (HAp, Ca10(PO4)6(OH)2) can be electrochemically deposited onto metallic 3D-woven bone scaffolds to enhance their bioactivity. The HAp coatings were deposited onto metallic scaffolds using an electrolyte containing Ca(NO3)2·4H2O, NH4H2PO4, and NaNO3. The deposition potential was varied to maximize the uniformity and adhesion of the coating. Using X-ray diffraction (XRD), Raman spectroscopy, and energy-dispersive spectroscopy (EDS), we found crystallized HAp on the 3D-woven lattice under all deposition potentials, while the −1.5 V mercury sulfate reference electrode potential provided the best local uniformity with a satisfactory deposition rate. The coatings generated under this optimized condition were approximately 5 µm thick and uniform throughout the internal and external sections of the woven lattice. We seeded and cultured both coated and uncoated scaffolds with human adipose-derived stromal/stem cells (ASCs) for 12 h and 4 days. We observed that the HAp coating increased the initial cell seeding efficiency by approximately 20%. Furthermore, after 4 days of culture, ASCs cultured on HAp-coated stainless-steel scaffolds increased by 32% compared to only 17% on the uncoated scaffold. Together, these results suggest that the HAp coating improves cellular adhesion. View Full-Text
Keywords: hydroxyapatite; 3D-woven lattice; bioscaffolds; electrodeposition; bone engineering hydroxyapatite; 3D-woven lattice; bioscaffolds; electrodeposition; bone engineering
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MDPI and ACS Style

Xue, J.; Farris, A.; Wang, Y.; Yeh, W.; Romany, C.; Guest, J.K.; Grayson, W.L.; Hall, A.S.; Weihs, T.P. Electrodeposition of Hydroxyapatite on a Metallic 3D-Woven Bioscaffold. Coatings 2020, 10, 715. https://doi.org/10.3390/coatings10080715

AMA Style

Xue J, Farris A, Wang Y, Yeh W, Romany C, Guest JK, Grayson WL, Hall AS, Weihs TP. Electrodeposition of Hydroxyapatite on a Metallic 3D-Woven Bioscaffold. Coatings. 2020; 10(8):715. https://doi.org/10.3390/coatings10080715

Chicago/Turabian Style

Xue, Ju, Ashley Farris, Yunfei Wang, Weiyan Yeh, Cristina Romany, James K. Guest, Warren L. Grayson, Anthony S. Hall, and Timothy P. Weihs 2020. "Electrodeposition of Hydroxyapatite on a Metallic 3D-Woven Bioscaffold" Coatings 10, no. 8: 715. https://doi.org/10.3390/coatings10080715

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