The Combination of Amoxicillin and 1,8-Cineole Improves the Bioavailability and the Therapeutic Effect of Amoxicillin in a Rabbit Model
Abstract
:1. Introduction
2. Results
2.1. Chemical Analysis of the Blood Samples
2.2. Biological Analysis of the Blood Samples
2.3. CSF Samples Biological Analysis
3. Discussion
4. Materials and Methods
4.1. Drugs and Reagents
4.2. Animals
4.3. Experimental Design
4.4. Sampling of Blood and Cerebrospinal Fluid (CSF)
4.5. HPLC Analysis
4.6. Pharmacokinetic Analysis
4.7. Blood or CSF Samples and Microbiological Assay
4.8. Ethical Approval
4.9. Statistical Analysis
5. Conclusions
6. Patents
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Rabbit Groups | AUC0–6h (µg.h/mL) | Cmax (µg/mL) | Tmax (h) | Ke | T1/2 (h) |
---|---|---|---|---|---|
Reference group | 14.74 ± 0.9 | 3.49 ± 0.2 | 1.55 ± 0.1 | 0.32 ± 0.04 | 2.21 ± 0.3 |
Test group | 22.30 ± 0.4 ** | 5.79 ± 0.2 ** | 1.18 ± 0.1 | 0.24 ± 0.01 | 2.94 ± 0.2 |
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Akhmouch, A.A.; Hriouech, S.; Chefchaou, H.; Tanghort, M.; Mzabi, A.; Chami, N.; Remmal, A. The Combination of Amoxicillin and 1,8-Cineole Improves the Bioavailability and the Therapeutic Effect of Amoxicillin in a Rabbit Model. Antibiotics 2022, 11, 1294. https://doi.org/10.3390/antibiotics11101294
Akhmouch AA, Hriouech S, Chefchaou H, Tanghort M, Mzabi A, Chami N, Remmal A. The Combination of Amoxicillin and 1,8-Cineole Improves the Bioavailability and the Therapeutic Effect of Amoxicillin in a Rabbit Model. Antibiotics. 2022; 11(10):1294. https://doi.org/10.3390/antibiotics11101294
Chicago/Turabian StyleAkhmouch, Ahmed Amin, Soukayna Hriouech, Hanane Chefchaou, Mariam Tanghort, Aouatef Mzabi, Najat Chami, and Adnane Remmal. 2022. "The Combination of Amoxicillin and 1,8-Cineole Improves the Bioavailability and the Therapeutic Effect of Amoxicillin in a Rabbit Model" Antibiotics 11, no. 10: 1294. https://doi.org/10.3390/antibiotics11101294