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Biosensors 2018, 8(4), 110; https://doi.org/10.3390/bios8040110

Sensors Based on Metal Nanoclusters Stabilized on Designed Proteins

1
CIC biomaGUNE, Parque Tecnológico de San Sebastián, Paseo Miramón 182, 20014 San Sebastián, Spain
2
Ikerbasque, Basque Foundation for Science, Mª Díaz de Haro 3, 48013 Bilbao, Spain
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 2 October 2018 / Revised: 7 November 2018 / Accepted: 12 November 2018 / Published: 15 November 2018
(This article belongs to the Special Issue Functional Nanomaterials for Biosensing and Bioimaging)
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Abstract

Among all new nanomaterials, metal nanoclusters (NCs) have attracted special attention due to their interesting optical properties, among others. Metal NCs have been recently studied and used as sensors for different analytes. However, there is a need to explore the potential of these new sensors in a systematic manner and to develop new systems to broaden the possibilities that sensing offers to the industry. In this work, we show the potential use of repeat protein scaffolds as versatile templates for the synthesis and stabilization of various metal NCs, specifically Au, Ag, and CuNCs. The resulting protein-metal NCs hybrids are evaluated as sensors for different stimuli such as temperature, ions, or reactive oxygen species (ROS). Among the three protein-metal NCs, all performed nicely as temperature sensors, AuNCs responded to metal ions, and AgNCs were able to detect ROS. View Full-Text
Keywords: protein design; metal nanocluster; fluorescent probe; nanosensor; temperature sensor; metal sensors; ROS sensors protein design; metal nanocluster; fluorescent probe; nanosensor; temperature sensor; metal sensors; ROS sensors
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Aires, A.; Lopez-Martinez, E.; Cortajarena, A.L. Sensors Based on Metal Nanoclusters Stabilized on Designed Proteins. Biosensors 2018, 8, 110.

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