Next Article in Journal
Development of a β-Lactoglobulin Sensor Based on SPR for Milk Allergens Detection
Next Article in Special Issue
The Use of a Polyphenoloxidase Biosensor Obtained from the Fruit of Jurubeba (Solanum paniculatum L.) in the Determination of Paracetamol and Other Phenolic Drugs
Previous Article in Journal
Coverage of Emotion Recognition for Common Wearable Biosensors
Previous Article in Special Issue
Simple Approaches to Minimally-Instrumented, Microfluidic-Based Point-of-Care Nucleic Acid Amplification Tests
Article Menu
Issue 2 (June) cover image

Export Article

Open AccessReview
Biosensors 2018, 8(2), 31;

Review of Stratum Corneum Impedance Measurement in Non-Invasive Penetration Application

State Key Laboratory of Transducer Technology, Institute of Electronics, Chinese Academy of Sciences, Beijing 100190, China
University of Chinese Academy of Sciences, Beijing 100049, China
School of Public Health, Capital Medical University, Beijing 100069, China
Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing 100069, China
Author to whom correspondence should be addressed.
Received: 24 January 2018 / Revised: 10 March 2018 / Accepted: 12 March 2018 / Published: 26 March 2018
Full-Text   |   PDF [11236 KB, uploaded 3 May 2018]   |  


Due to advances in telemedicine, mobile medical care, wearable health monitoring, and electronic skin, great efforts have been directed to non-invasive monitoring and treatment of disease. These processes generally involve disease detection from interstitial fluid (ISF) instead of blood, and transdermal drug delivery. However, the quantitative extraction of ISF and the level of drug absorption are greatly affected by the individual’s skin permeability, which is closely related to the properties of the stratum corneum (SC). Therefore, measurement of SC impedance has been proposed as an appropriate way for assessing individual skin differences. In order to figure out the current status and research direction of human SC impedance detection, investigations regarding skin impedance measurement have been reviewed in this paper. Future directions are concluded after a review of impedance models, electrodes, measurement methods and systems, and their applications in treatment. It is believed that a well-matched skin impedance model and measurement method will be established for clinical and point-of care applications in the near future. View Full-Text
Keywords: mobile medical care; Non-invasive monitoring; skin impedance; skin permeability; Impedance model mobile medical care; Non-invasive monitoring; skin impedance; skin permeability; Impedance model

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Lu, F.; Wang, C.; Zhao, R.; Du, L.; Fang, Z.; Guo, X.; Zhao, Z. Review of Stratum Corneum Impedance Measurement in Non-Invasive Penetration Application. Biosensors 2018, 8, 31.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Biosensors EISSN 2079-6374 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top