Next Article in Journal
Study on Detection Method of Sulfamethazine Residues in Duck Blood Based on Surface-Enhanced Raman Spectroscopy
Previous Article in Journal
Advancements in Single-Molecule Fluorescence Detection Techniques and Their Expansive Applications in Drug Discovery and Neuroscience
 
 
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

Aptamer-Based Planar Electric Double-Layer Field-Effect Transistor: A Novel Approach for Sensitive Troponin I Sensing

Department of Electrical Engineering, Feng Chia University, Taichung City 407102, Taiwan
*
Author to whom correspondence should be addressed.
Biosensors 2025, 15(5), 285; https://doi.org/10.3390/bios15050285
Submission received: 20 March 2025 / Revised: 27 April 2025 / Accepted: 29 April 2025 / Published: 30 April 2025

Abstract

This study introduces a cutting-edge, aptamer-based, planar electric, double-layer field-effect transistor (FET) system that offers both high sensitivity and specificity for the detection of troponin I (TnI). The proposed sensing platform leverages the signal amplification capabilities of FETs alongside the unique attributes of a planar electric double-layer design to address the limitations inherent in traditional ion-sensitive detectors, which are impacted by Debye length effects. By integrating TnI-specific aptamers, the system markedly enhances molecular recognition and transduction efficiency, achieving an impressive detection limit of . Furthermore, the sensor demonstrates a strong exponential linear response across a clinically relevant concentration range of 1 ng/mL to 100 ng/mL. This innovative approach underscores the potential of electric double-layer FET systems to advance biomarker detection technologies for medical diagnostics and point-of-care applications.
Keywords: aptamer-based sensing; planar electric double-layer; field-effect transistor; troponin I detection; debye length effects; point-of-care diagnostics aptamer-based sensing; planar electric double-layer; field-effect transistor; troponin I detection; debye length effects; point-of-care diagnostics

Share and Cite

MDPI and ACS Style

Hung, S.-C.; Lee, Y.-H. Aptamer-Based Planar Electric Double-Layer Field-Effect Transistor: A Novel Approach for Sensitive Troponin I Sensing. Biosensors 2025, 15, 285. https://doi.org/10.3390/bios15050285

AMA Style

Hung S-C, Lee Y-H. Aptamer-Based Planar Electric Double-Layer Field-Effect Transistor: A Novel Approach for Sensitive Troponin I Sensing. Biosensors. 2025; 15(5):285. https://doi.org/10.3390/bios15050285

Chicago/Turabian Style

Hung, Sheng-Chun, and Yi-Hua Lee. 2025. "Aptamer-Based Planar Electric Double-Layer Field-Effect Transistor: A Novel Approach for Sensitive Troponin I Sensing" Biosensors 15, no. 5: 285. https://doi.org/10.3390/bios15050285

APA Style

Hung, S.-C., & Lee, Y.-H. (2025). Aptamer-Based Planar Electric Double-Layer Field-Effect Transistor: A Novel Approach for Sensitive Troponin I Sensing. Biosensors, 15(5), 285. https://doi.org/10.3390/bios15050285

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop