Next Article in Journal
Can Pulsed Electromagnetic Fields Trigger On-Demand Drug Release from High-Tm Magnetoliposomes?
Next Article in Special Issue
Spherical and Spindle-Like Abamectin-Loaded Nanoparticles by Flash Nanoprecipitation for Southern Root-Knot Nematode Control: Preparation and Characterization
Previous Article in Journal
Fabrication of Amine-Modified Magnetite-Electrochemically Reduced Graphene Oxide Nanocomposite Modified Glassy Carbon Electrode for Sensitive Dopamine Determination
Previous Article in Special Issue
A Modular Coassembly Approach to All-In-One Multifunctional Nanoplatform for Synergistic Codelivery of Doxorubicin and Curcumin
Article Menu
Issue 4 (April) cover image

Export Article

Open AccessArticle
Nanomaterials 2018, 8(4), 195; https://doi.org/10.3390/nano8040195

Synthesis, Self-Assembly, and Drug-Release Properties of New Amphipathic Liquid Crystal Polycarbonates

1
Center for Molecular Science and Engineering, College of Science, Northeastern University, Shenyang 110819, China
2
Key Laboratory of Reproductive Health, Liaoning Research Institute of Family Planning, Shenyang 110031, China
*
Authors to whom correspondence should be addressed.
Received: 28 January 2018 / Revised: 23 March 2018 / Accepted: 25 March 2018 / Published: 27 March 2018
Full-Text   |   PDF [19404 KB, uploaded 3 May 2018]   |  

Abstract

New amphiphilic liquid crystal (LC) polycarbonate block copolymers containing side-chain cholesteryl units were synthesized. Their structure, thermal stability, and LC phase behavior were characterized with Fourier transform infrared (FT-IR) spectrum, 1H NMR, gel permeation chromatographic (GPC), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), polarizing optical microscope (POM), and XRD methods. The results demonstrated that the LC copolymers showed a double molecular arrangement of a smectic A phase at room temperature. With the elevating of LC unit content in such LC copolymers, the corresponding properties including decomposition temperature (Td), glass temperature (Tg), and isotropic temperature (Ti) increased. The LC copolymers showed pH-responsive self-assembly behavior under the weakly acidic condition, and with more side-chain LC units, the self-assembly process was faster, and the formed particle size was smaller. It indicated that the self-assembly driving force was derived from the orientational ability of LC. The particle size and morphologies of self-assembled microspheres loaded with doxorubicin (DOX), together with drug release tracking, were evaluated by dynamic light scattering (DLS), SEM, and UV–vis spectroscopy. The results showed that DOX could be quickly released in a weakly acidic environment due to the pH response of the self-assembled microspheres. This would offer a new strategy for drug delivery in clinic applications. View Full-Text
Keywords: amphipathic polycarbonates; cholesteryl; liquid crystal; self-assembly; drug release amphipathic polycarbonates; cholesteryl; liquid crystal; self-assembly; drug release
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material

SciFeed

Share & Cite This Article

MDPI and ACS Style

Xie, Y.; Liu, X.; Hu, Z.; Hou, Z.; Guo, Z.; Chen, Z.; Hu, J.; Yang, L. Synthesis, Self-Assembly, and Drug-Release Properties of New Amphipathic Liquid Crystal Polycarbonates. Nanomaterials 2018, 8, 195.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Nanomaterials EISSN 2079-4991 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top