Endothelial Progenitor Cells as a Marker of Vascular Damage But not a Predictor in Acute Microangiopathy-Associated Stroke
Abstract
:1. Introduction
2. Material and Methods
2.1. Study Design and Participants
2.2. Flow Cytometry
2.3. Clinical Outcome
2.4. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Parameter | Ischemic Stroke | Hemorrhage | Control Group | p-Values |
---|---|---|---|---|
Sex, male, (%) 1 | 62.1 | 55.3 | 36.4 | 0.1088 |
Sex, female, (%) 1 | 37.9 | 44.7 | 63.6 | 0.1267 |
Age (median, range) 3 | 69 (45–88) | 73.5 (45–91) | 63.5 (50–82) | 0.1034 |
Smoking, (%) 1 | 32.6 | 28.9 | 24.5 | 0.3457 |
Hypertension, (%) 1 | 90.9 | 94.7 | 81.8 | 0.2555 |
Hyperlipidemia, (%) 1 | 60.6 | 50 | 54.5 | 0.566 |
Diabetes, (%)1 | 37.9 | 21.8 | 27.3 | 0.186 |
CRP (mg/L), (median, range) 2 | 4.50 (0.39–58.12) | 5.79 (0.38–70.1) | - | 0.2117 |
Homocystein (µg/mL) (median, range) 2 | 11.05 (3.52–30.92) | 9.22 (2.65–42.8) | - | 0.6341 |
Fibrinogen (g/L), (median, range) 2 | 284 (59–590) | 315.5 (157–463) | - | 0.2985 |
NIHSS 1st day (points) (median, range) 2 | 6 (2–21) | 6 (1–21) | - | 0.6103 |
NIHSS 8th day (points) (median, range) 2 | 3 (0–15) | 3 (0–14) | - | 0.7086 |
mRS 1st day (points) (median, range) 2 | 4 (2–5) | 5 (3–5) | - | 0.0001 * |
mRS 8th day (points) (median, range) 2 | 2 (0–5) | 3 (0–4) | - | 0.2377 |
EPCs/µL 1st Day | EPCs/µL 8th Day | |||||
---|---|---|---|---|---|---|
Parameter | Present | Absent | p-Values * | Present | Absent | p-Values * |
Hypertension | 17.14 (0–278.11) | 23.24 (2.77–112.21) | 0.8847 | 24.45 (0.46–316.89) | 62.47 (18–323.29) | 0.0536 |
Hyperlipidemia | 14.69 (0–178.86) | 25.55 (4.12–278.11) | 0.1785 | 25.02 (0.40–316.89) | 25.72 (2.03–323.29) | 0.4724 |
Diabetes | 14.47 (0–178.86) | 25.12 (1.01–278.11) | 0.0701 | 31.16 (0.40–323.29) | 24.51 (0.46–316.89) | 0.7014 |
Smoking | 16.32 (0–178.86) | 22.13 (2.77–112.21) | 0.1654 | 27.85 (0.40–323.29) | 31.69 (2.03–323.29) | 0.1324 |
EPCs/µL 1st Day | EPCs/µL 8th Day | |||||
---|---|---|---|---|---|---|
Parameter | Present | Absent | p-Values * | Present | Absent | p-Values * |
Hypertension | 17.75 (0–488.41) | 4.43 (3.75–5.11) | 0.0722 | 17.93 (0–325.43) | 22.44 (0.10–44.78) | 0.4522 |
Hyperlipidemia | 31.23 (0.62–338.00) | 15.51 (0–488.41) | 0,7042 | 37.62 (1.21–325.43) | 11.64 (0–233.20) | 0.1443 |
Diabetes | 17.48 (6.36–58.38) | 16.47 (0–488.41) | 0.7608 | 17.15 (3.01–10020) | 17.93 (0–325.43) | 0.7608 |
Smoking | 25.67 (0.62–338.00) | 21.98 (0–488.41) | 0.6983 | 23.68 (1.21–325.43) | 17.44 (0.10–233.20) | 0.6684 |
EPCs/µL 1st Day | EPCs/µL 8th Day | |||||||
---|---|---|---|---|---|---|---|---|
Ischemic Stroke | Hemorrhage | Ischemic Stroke | Hemorrhage | |||||
R | p | R | p | R | p | R | p | |
CRP | 0.1630 | 0.1909 | −0.0242 | 0.8854 | 0.0986 | 0.4308 | −0.1526 | 0.3602 |
fibrinogen | −0.1731 | 0.1644 | 0.1135 | 0.4974 | 0.1095 | 0.3816 | −0.0459 | 0.7840 |
homocystein | −0.0879 | 0.4827 | 0.0578 | 0.7309 | −0.0376 | 0.7639 | 0.2465 | 0.1356 |
EPCs/µL 1st Day | EPCs/µL 8th Day | |||||||
---|---|---|---|---|---|---|---|---|
Ischemic Stroke | Hemorrhagic Stroke | Ischemic Stroke | Hemorrhagic Stroke | |||||
R | p | R | p | R | p | R | p | |
NIHSS 1st day | −0.0469 | 0.7084 | 0.0932 | 0.5778 | 0.1842 | 0.1387 | 0.2108 | 0.2038 |
NIHSS 8th day | −0.1469 | 0.2388 | −0.0888 | 0.5959 | 0.1446 | 0.2465 | 0.0857 | 0.6085 |
mRS 1st day | 0.1359 | 0.2765 | −0.1228 | 0.4624 | 0.0230 | 0.8544 | 0.0837 | 0.6171 |
mRS 8th day | −0.1355 | 0.2766 | 0.1300 | 0.1882 | 0.0858 | 0.4933 | 0.0648 |
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Wiśniewski, A.; Boinska, J.; Ziołkowska, K.; Lemanowicz, A.; Filipska, K.; Serafin, Z.; Ślusarz, R.; Rość, D.; Kozera, G. Endothelial Progenitor Cells as a Marker of Vascular Damage But not a Predictor in Acute Microangiopathy-Associated Stroke. J. Clin. Med. 2020, 9, 2248. https://doi.org/10.3390/jcm9072248
Wiśniewski A, Boinska J, Ziołkowska K, Lemanowicz A, Filipska K, Serafin Z, Ślusarz R, Rość D, Kozera G. Endothelial Progenitor Cells as a Marker of Vascular Damage But not a Predictor in Acute Microangiopathy-Associated Stroke. Journal of Clinical Medicine. 2020; 9(7):2248. https://doi.org/10.3390/jcm9072248
Chicago/Turabian StyleWiśniewski, Adam, Joanna Boinska, Katarzyna Ziołkowska, Adam Lemanowicz, Karolina Filipska, Zbigniew Serafin, Robert Ślusarz, Danuta Rość, and Grzegorz Kozera. 2020. "Endothelial Progenitor Cells as a Marker of Vascular Damage But not a Predictor in Acute Microangiopathy-Associated Stroke" Journal of Clinical Medicine 9, no. 7: 2248. https://doi.org/10.3390/jcm9072248