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J. Clin. Med. 2019, 8(2), 207;

Chimeric Antigen Receptor T-Cells: The Future Is Now

Department of Medicine, Northside Hospital Cancer Institute, Atlanta, GA 30342, USA
Department of Medicine, University of Pittsburgh Center East, Monroeville, PA 15146, USA
Blood and Marrow Transplant, Acute Leukemia and Immunotherapy Program, Northside Hospital, Atlanta, GA 30342, USA
Author to whom correspondence should be addressed.
Received: 15 January 2019 / Revised: 29 January 2019 / Accepted: 31 January 2019 / Published: 7 February 2019
(This article belongs to the Special Issue Hematopoietic Cell Transplantation and Cellular Therapy: A New Era)
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The immune system acting via cancer immune-surveillance is considered a potential target for improving outcomes among some malignancies. The ability to harness immune cells, engineer them and educate them to target cancer cells has changed the paradigm for treating non-Hodgkin’s lymphomas (NHL) and acute lymphoblastic leukemia (ALL). Chimeric antigen receptor (CAR) T-cell therapy has shown remarkable anti-tumor activity against refractory B cell malignancies. Ongoing research aims to expand the scope of this adoptive cell therapy, understanding mechanisms of resistance and reducing toxicity. In this review, we will discuss the current scope of CAR T-cell therapy and ongoing future applications. View Full-Text
Keywords: Chimeric; cellular; immunotherapy; T cell Chimeric; cellular; immunotherapy; T cell

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Mchayleh, W.; Bedi, P.; Sehgal, R.; Solh, M. Chimeric Antigen Receptor T-Cells: The Future Is Now. J. Clin. Med. 2019, 8, 207.

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