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J. Clin. Med. 2019, 8(1), 26; https://doi.org/10.3390/jcm8010026

Exosome-Mediated Signaling in Epithelial to Mesenchymal Transition and Tumor Progression

1,†,* and 2,†,*
1
Dipartimento di Biopatologia e Biotecnologie Mediche, University of Palermo, 90100 Palermo, Italy
2
Dipartimento di Medicina Molecolare, Sapienza University of Rome, 00161 Rome, Italy
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 16 November 2018 / Revised: 18 December 2018 / Accepted: 21 December 2018 / Published: 27 December 2018
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Abstract

Growing evidence points to exosomes as key mediators of cell–cell communication, by transferring their specific cargo (e.g., proteins, lipids, DNA and RNA molecules) from producing to receiving cells. In cancer, the regulation of the exosome-mediated intercellular communication may be reshaped, inducing relevant changes in gene expression of recipient cells in addition to microenvironment alterations. Notably, exosomes may deliver signals able to induce the transdifferentiation process known as Epithelial-to-Mesenchymal Transition (EMT). In this review, we summarize recent findings on the role of exosomes in tumor progression and EMT, highlighting current knowledge on exosome-mediated intercellular communication in tumor-niche establishment, migration, invasion, and metastasis processes. This body of evidence suggests the relevance of taking into account exosome-mediated signaling and its multifaceted aspects to develop innovative anti-tumoral therapeutic approaches. View Full-Text
Keywords: tumor niche; Epithelial–Mesenchymal plasticity; cancer-derived exosomes; extracellular vesicles; metastasis tumor niche; Epithelial–Mesenchymal plasticity; cancer-derived exosomes; extracellular vesicles; metastasis
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Conigliaro, A.; Cicchini, C. Exosome-Mediated Signaling in Epithelial to Mesenchymal Transition and Tumor Progression. J. Clin. Med. 2019, 8, 26.

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