Next Article in Journal
Risk of Dementia in Older Patients with Type 2 Diabetes on Dipeptidyl-Peptidase IV Inhibitors Versus Sulfonylureas: A Real-World Population-Based Cohort Study
Next Article in Special Issue
Cardiovascular Comorbidities in Chronic Obstructive Pulmonary Disease (COPD)—Current Considerations for Clinical Practice
Previous Article in Journal
Exosome-Mediated Signaling in Epithelial to Mesenchymal Transition and Tumor Progression
Previous Article in Special Issue
Effects of Corticosteroid Treatment and Antigen Avoidance in a Large Hypersensitivity Pneumonitis Cohort: A Single-Centre Cohort Study
Article Menu

Export Article

Open AccessArticle
J. Clin. Med. 2019, 8(1), 27;

Comprehensive Lung Function Assessment Does not Allow to Infer Response to Pulmonary Rehabilitation in Patients with COPD

CIRO+, center of expertise for chronic organ failure, 6085 NM Horn, The Netherlands
NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, 6229 ER Maastricht, The Netherlands
Department of Respiratory Medicine, Maastricht University Medical Centre+, 6229 HX Maastricht, The Netherlands
Viscovery Software GmbH, 1130 Vienna, Austria
Author to whom correspondence should be addressed.
Received: 19 November 2018 / Revised: 15 December 2018 / Accepted: 22 December 2018 / Published: 27 December 2018
Full-Text   |   PDF [2065 KB, uploaded 27 December 2018]   |  


The degree of lung function is frequently used as referral criterion for pulmonary rehabilitation. The efficacy of pulmonary rehabilitation was assessed in 518 chronic obstructive pulmonary disease (COPD) patients, after clustering based on a comprehensive pre-rehabilitation lung function assessment. Mean improvements in dyspnea, exercise performance, health status, mood status and problematic activities of daily life after pulmonary rehabilitation were mostly comparable between the seven clusters, despite significant differences in the degree of lung function. The current study demonstrates no significant relationship between the seven lung-function-based clusters and response to pulmonary rehabilitation. Therefore, baseline lung function cannot be used to identify those who will respond well to pulmonary rehabilitation, and moreover, cannot be used as a criterion for referral to pulmonary rehabilitation in patients with COPD. View Full-Text
Keywords: pulmonary rehabilitation; COPD; response pulmonary rehabilitation; COPD; response

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Augustin, I.M.L.; Wouters, E.F.M.; Houben-Wilke, S.; Gaffron, S.; Janssen, D.J.A.; Franssen, F.M.E.; Spruit, M.A. Comprehensive Lung Function Assessment Does not Allow to Infer Response to Pulmonary Rehabilitation in Patients with COPD. J. Clin. Med. 2019, 8, 27.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
J. Clin. Med. EISSN 2077-0383 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top