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J. Clin. Med. 2019, 8(1), 22; https://doi.org/10.3390/jcm8010022

Irreversible Electroporation in Liver Cancers and Whole Organ Engineering

1
Department of Vascular and Interventional Radiology, Laboratory for Minimally Invasive Therapeutics, Mayo Clinic, Phoenix, AZ 85054, USA
2
Department of Interventional Radiology, MD Anderson Cancer Center, Houston, TX 77030, USA
*
Author to whom correspondence should be addressed.
Received: 1 December 2018 / Revised: 15 December 2018 / Accepted: 19 December 2018 / Published: 25 December 2018
(This article belongs to the Section Gastroenterology & Hepato-Pancreato-Biliary Medicine)
Full-Text   |   PDF [864 KB, uploaded 25 December 2018]   |  

Abstract

Liver cancers contribute significantly to cancer-related mortality worldwide and liver transplants remain the cornerstone of curative treatment for select, early-stage patients. Unfortunately, because of a mismatch between demand and supply of donor organs, liver cancer patients must often wait extended periods of time prior to transplant. A variety of local therapies including surgical resection, transarterial chemoembolization, and thermal ablative methods exist in order to bridge to transplant. In recent years, a number of studies have examined the role of irreversible electroporation (IRE) as a non-thermal local ablative method for liver tumors, particularly for those adjacent to critical structures such as the vasculature, gall bladder, or bile duct. In addition to proving its utility as a local treatment modality, IRE has also demonstrated promise as a technique for donor organ decellularization in the context of whole-organ engineering. Through complete non-thermal removal of living cells, IRE allows for the creation of an acellular extra cellular matrix (ECM) scaffold that could theoretically be recellularized and implanted into a living host. Here, we comprehensively review studies investigating IRE, its role in liver cancer treatment, and its utility in whole organ engineering. View Full-Text
Keywords: irreversible electroporation; liver cancer; HCC; whole-organ engineering irreversible electroporation; liver cancer; HCC; whole-organ engineering
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Saini, A.; Breen, I.; Alzubaidi, S.; Pershad, Y.; Sheth, R.; Naidu, S.; Knuttinen, M.G.; Albadawi, H.; Oklu, R. Irreversible Electroporation in Liver Cancers and Whole Organ Engineering. J. Clin. Med. 2019, 8, 22.

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