Heart–Lung–Muscle Anti-SAE Syndrome: An Atypical Severe Combination
AbstractA 78-year-old man with 3 months of progressive dyspnea, dysphony, dysgeusia, and proximal muscle weakness was diagnosed of probably idiopathic inflammatory myopathy with nonspecific interstitial pneumonia. Variable degrees of atrioventricular block and persistently elevated cardiac enzymes indicated a diagnosis of myocarditis, confirmed with cardiac magnetic resonance imaging and endomyocardial biopsy. A comprehensive immune work-up revealed anti-small ubiquitin-like modifier-1 activating enzyme (anti-SAE) antibody, a novel myositis-specific antibody, previously described mainly with overt cutaneous dermatomyositis and late skeletal muscle manifestations. Here, heart–lung–muscle involvement combined with anti-SAE antibodies was a severe combination. View Full-Text
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Zamora, E.; Seder-Colomina, E.; Holgado, S.; Quirant-Sanchez, B.; Mate, J.L.; Martínez-Cáceres, E.M.; Casafont, I.; Bayés-Genís, A. Heart–Lung–Muscle Anti-SAE Syndrome: An Atypical Severe Combination. J. Clin. Med. 2019, 8, 20.
Zamora E, Seder-Colomina E, Holgado S, Quirant-Sanchez B, Mate JL, Martínez-Cáceres EM, Casafont I, Bayés-Genís A. Heart–Lung–Muscle Anti-SAE Syndrome: An Atypical Severe Combination. Journal of Clinical Medicine. 2019; 8(1):20.Chicago/Turabian Style
Zamora, Elisabet; Seder-Colomina, Elena; Holgado, Susana; Quirant-Sanchez, Bibiana; Mate, José L.; Martínez-Cáceres, Eva M.; Casafont, Ivette; Bayés-Genís, Antoni. 2019. "Heart–Lung–Muscle Anti-SAE Syndrome: An Atypical Severe Combination." J. Clin. Med. 8, no. 1: 20.
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