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Open AccessCase Report
J. Clin. Med. 2019, 8(1), 20; https://doi.org/10.3390/jcm8010020

Heart–Lung–Muscle Anti-SAE Syndrome: An Atypical Severe Combination

1
Cardiology Department, Hospital Universitari Germans Trias i Pujol, 08916 Badalona, Spain
2
Departament de Medicina, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain
3
CIBERCV, Instituto de Salud Carlos III, 28029 Madrid, Spain
4
Rheumatology Department, Hospital Universitari Germans Trias i Pujol, 08916 Badalona, Spain
5
Immunology Department, Hospital Universitari Germans Trias i Pujol, 08916 Badalona, Spain
6
Department of Cell Biology, Physiology and Immunology, Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
7
Pathology Department, Hospital Universitari Germans Trias i Pujol, 08916 Badalona, Spain
*
Author to whom correspondence should be addressed.
Received: 23 November 2018 / Revised: 21 December 2018 / Accepted: 21 December 2018 / Published: 23 December 2018
(This article belongs to the Section Cardiology)
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Abstract

A 78-year-old man with 3 months of progressive dyspnea, dysphony, dysgeusia, and proximal muscle weakness was diagnosed of probably idiopathic inflammatory myopathy with nonspecific interstitial pneumonia. Variable degrees of atrioventricular block and persistently elevated cardiac enzymes indicated a diagnosis of myocarditis, confirmed with cardiac magnetic resonance imaging and endomyocardial biopsy. A comprehensive immune work-up revealed anti-small ubiquitin-like modifier-1 activating enzyme (anti-SAE) antibody, a novel myositis-specific antibody, previously described mainly with overt cutaneous dermatomyositis and late skeletal muscle manifestations. Here, heart–lung–muscle involvement combined with anti-SAE antibodies was a severe combination. View Full-Text
Keywords: myocarditis; idiopathic inflammatory myopathy; anti-SAE antibody myocarditis; idiopathic inflammatory myopathy; anti-SAE antibody
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Zamora, E.; Seder-Colomina, E.; Holgado, S.; Quirant-Sanchez, B.; Mate, J.L.; Martínez-Cáceres, E.M.; Casafont, I.; Bayés-Genís, A. Heart–Lung–Muscle Anti-SAE Syndrome: An Atypical Severe Combination. J. Clin. Med. 2019, 8, 20.

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