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Moonlighting with WDR5: A Cellular Multitasker

Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
Author to whom correspondence should be addressed.
J. Clin. Med. 2018, 7(2), 21;
Received: 19 December 2017 / Revised: 16 January 2018 / Accepted: 18 January 2018 / Published: 30 January 2018
(This article belongs to the Special Issue Trends in Precision Oncology from Data Science)
WDR5 is a highly conserved WD40 repeat-containing protein that is essential for proper regulation of multiple cellular processes. WDR5 is best characterized as a core scaffolding component of histone methyltransferase complexes, but emerging evidence demonstrates that it does much more, ranging from expanded functions in the nucleus through to controlling the integrity of cell division. The purpose of this review is to describe the current molecular understandings of WDR5, discuss how it participates in diverse cellular processes, and highlight drug discovery efforts around WDR5 that may form the basis of new anti-cancer therapies. View Full-Text
Keywords: WDR5; WD40 repeat; epigenetics; transcription; cancer; drug discovery WDR5; WD40 repeat; epigenetics; transcription; cancer; drug discovery
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Guarnaccia, A.D.; Tansey, W.P. Moonlighting with WDR5: A Cellular Multitasker. J. Clin. Med. 2018, 7, 21.

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