Evaluation of Colorectal Cancer Incidence Trends in the United States (2000–2014)
Abstract
:1. Introduction
2. Materials and Methods
2.1. Data Source
2.2. Study Population and Measures
2.3. Statistical Analyses
3. Results
3.1. Demographic and Cancer Characteristics
3.2. CRC Rates/Trends for each Year from 2000 to 2014
3.3. Overall CRC Rates/Trends for the Entire Time Period between 2000 and 2014
4. Discussion
5. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Characteristics | Total N = 577,708 (%) | 2000–2004 n = 197,716 (%) | 2005–2009 n = 193,012 (%) | 2010–2014 n = 186,980 (%) |
---|---|---|---|---|
Sex | ||||
Male | 297,320 (51.5) | 100,633 (51.0) | 99,304 (51.4) | 97,383 (52.1) |
Female | 280,388 (48.5) | 97,083 (49.1) | 93,708 (48.6) | 89,597 (47.9) |
Race | ||||
White | 462,221 (80.0) | 162,577 (82.2) | 154,310 (79.9) | 145,334 (77.7) |
Black | 66,475 (11.5) | 21,399 (10.8) | 22,327 (11.6) | 22,749 (12.2) |
* Other | 44,989 (7.8) | 12,950 (6.6) | 15,171 (7.9) | 16,868 (9.0) |
Unknown | 4023 (0.7) | 790 (0.4) | 1204 (0.6) | 2029 (1.1) |
Age | ||||
<40 | 15,312 (2.6) | 4631 (2.3) | 4944 (2.6) | 5737 (3.1) |
40–49 | 42,626 (7.4) | 13,174 (6.7) | 14,556 (7.5) | 14,896 (8.0) |
50–59 | 103,684 (18.0) | 30,620 (15.5) | 35,399 (18.3) | 37,665 (20.1) |
60–69 | 131,512 (22.8) | 42,519 (21.5) | 43,316 (22.4) | 45,677 (24.4) |
70–79 | 148,149 (25.6) | 57,591 (29.1) | 48,458 (25.1) | 42,100 (22.5) |
80+ | 136,425 (23.6) | 49,181 (24.9) | 46,339 (24.0) | 40,905 (22.0) |
Stage | ||||
Localized | 236,262 (40.9) | 80,112 (40.5) | 80,050 (41.5) | 76,100 (40.7) |
Regional | 192,289 (33.3) | 68,430 (34.6) | 63,916 (33.1) | 59,943 (32.0) |
Distant | 111,909 (19.4) | 35,994 (18.2) | 36,878 (19.1) | 39,037 (20.9) |
Unstaged | 37,248 (6.4) | 13,180 (6.7) | 12,168 (6.3) | 11,900 (6.4) |
** Primary site | ||||
Proximal colon | 247,656 (42.9) | 84,430 (42.7) | 83,209 (43.1) | 80,017 (42.8) |
Distal colon | 138,377 (23.9) | 49,673 (25.1) | 46,207 (23.9) | 42,497 (22.7) |
Rectum | 165,932 (28.7) | 54,840 (27.7) | 55,177 (28.6) | 55,915 (29.9) |
*** Other | 25,743 (4.5) | 8,773 (4.5) | 8,419 (4.4) | 8,551 (4.6) |
Population Groups | Rate | Standard Error | 95% C.I (Rate) Lower/Upper | Rate Ratio | 95% C.I (Rate Ratio) Lower/Upper | APC | p-Value (APC) | ||
---|---|---|---|---|---|---|---|---|---|
All groups | 45.9 | 0.1 | 45.8 | 46.0 | −2.7 | <0.001 | |||
Sex | |||||||||
Male | 53.4 | 0.1 | 53.2 | 53.6 | Ref. | −2.9 | <0.001 | ||
Female | 39.9 | 0.1 | 39.8 | 40.1 | 0.75 | 0.74 | 0.75 | −2.5 | <0.001 |
Race | |||||||||
White | 45.6 | 0.1 | 45.5 | 45.7 | Ref. | −2.7 | <0.001 | ||
Black | 56.1 | 0.2 | 55.6 | 56.5 | 1.23 | 1.22 | 1.24 | −2.5 | <0.001 |
* Other | 37.5 | 0.2 | 37.2 | 37.9 | 0.82 | 0.81 | 0.83 | −2.3 | <0.001 |
Age (Years) | |||||||||
<40 | 2.3 | 0.0 | 2.3 | 2.4 | Ref. | 2.7 | <0.001 | ||
40–49 | 22.5 | 0.2 | 22.1 | 22.8 | 9.72 | 9.41 | 10.03 | 1.7 | <0.001 |
50–59 | 64.1 | 0.2 | 63.7 | 64.5 | 27.27 | 9.67 | 9.87 | −0.5 | <0.001 |
60–69 | 128.6 | 0.4 | 127.9 | 129.3 | 53.55 | 19.41 | 19.80 | −3.3 | <0.001 |
70–79 | 232.2 | 0.6 | 231.0 | 233.4 | 100.45 | 35.07 | 35.75 | −3.8 | <0.001 |
80+ | 329.8 | 0.9 | 328.1 | 331.6 | 142.98 | 49.81 | 50.79 | −3.8 | <0.001 |
Stage | |||||||||
Localized | 18.7 | 0.0 | 18.7 | 18.8 | Ref. | −2.6 | <0.001 | ||
Regional | 15.4 | 0.0 | 15.3 | 15.4 | 0.82 | 0.82 | 0.83 | −3.3 | <0.001 |
Distant | 8.9 | 0.0 | 8.8 | 8.9 | 0.47 | 0.47 | 0.48 | −1.3 | <0.001 |
Unstaged | 2.9 | 0.0 | 2.9 | 3.0 | 0.16 | 0.15 | 0.16 | −3.5 | <0.001 |
** Primary site | |||||||||
Proximal colon | 20.0 | 0.0 | 19.9 | 20.1 | Ref. | −2.5 | <0.001 | ||
Distal colon | 10.9 | 0.0 | 10.9 | 11.0 | 0.55 | 0.54 | 0.55 | −3.6 | <0.001 |
Rectum | 13.0 | 0.0 | 12.9 | 13.0 | 0.65 | 0.64 | 0.65 | −2.0 | <0.001 |
*** Other | 2.1 | 0.0 | 2.0 | 2.1 | 0.10 | 0.10 | 0.10 | −2.5 | <0.001 |
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Ansa, B.E.; Coughlin, S.S.; Alema-Mensah, E.; Smith, S.A. Evaluation of Colorectal Cancer Incidence Trends in the United States (2000–2014). J. Clin. Med. 2018, 7, 22. https://doi.org/10.3390/jcm7020022
Ansa BE, Coughlin SS, Alema-Mensah E, Smith SA. Evaluation of Colorectal Cancer Incidence Trends in the United States (2000–2014). Journal of Clinical Medicine. 2018; 7(2):22. https://doi.org/10.3390/jcm7020022
Chicago/Turabian StyleAnsa, Benjamin E., Steven S. Coughlin, Ernest Alema-Mensah, and Selina A. Smith. 2018. "Evaluation of Colorectal Cancer Incidence Trends in the United States (2000–2014)" Journal of Clinical Medicine 7, no. 2: 22. https://doi.org/10.3390/jcm7020022