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Viral Oncology: Molecular Biology and Pathogenesis

Center for Clinical Studies, Houston, TX 77004, USA
Department of Dermatology, University of Texas Health Science Center at Houston, Houston, TX 77004, USA
Author to whom correspondence should be addressed.
J. Clin. Med. 2017, 6(12), 111;
Received: 24 October 2017 / Revised: 17 November 2017 / Accepted: 22 November 2017 / Published: 29 November 2017
Oncoviruses are implicated in approximately 12% of all human cancers. A large number of the world’s population harbors at least one of these oncoviruses, but only a small proportion of these individuals go on to develop cancer. The interplay between host and viral factors is a complex process that works together to create a microenvironment conducive to oncogenesis. In this review, the molecular biology and oncogenic pathways of established human oncoviruses will be discussed. Currently, there are seven recognized human oncoviruses, which include Epstein-Barr Virus (EBV), Human Papillomavirus (HPV), Hepatitis B and C viruses (HBV and HCV), Human T-cell lymphotropic virus-1 (HTLV-1), Human Herpesvirus-8 (HHV-8), and Merkel Cell Polyomavirus (MCPyV). Available and emerging therapies for these oncoviruses will be mentioned. View Full-Text
Keywords: viral oncology; human oncovirus; EBV; HPV; HBV; HCV; HTLV-1; HHV-8; MCPyV viral oncology; human oncovirus; EBV; HPV; HBV; HCV; HTLV-1; HHV-8; MCPyV
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Mui, U.N.; Haley, C.T.; Tyring, S.K. Viral Oncology: Molecular Biology and Pathogenesis. J. Clin. Med. 2017, 6, 111.

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