Next Article in Journal
Ethnic Similarities and Differences in the Relationship between Beta Cell Mass and Diabetes
Previous Article in Journal
Viral Oncology: Molecular Biology and Pathogenesis
Previous Article in Special Issue
MUC1: The First Respiratory Mucin with an Anti-Inflammatory Function
Open AccessFeature PaperReview

Airway Mucus and Asthma: The Role of MUC5AC and MUC5B

Lung Biology Center, University of California San Francisco, San Francisco, CA 94143, USA
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2017, 6(12), 112; https://doi.org/10.3390/jcm6120112
Received: 1 November 2017 / Revised: 25 November 2017 / Accepted: 27 November 2017 / Published: 29 November 2017
(This article belongs to the Special Issue Role of Respiratory Mucins in Health and Disease)
Asthma is characterized by mucus abnormalities. Airway epithelial hyperplasia and metaplasia result in changes in stored and secreted mucin and the production of a pathologic mucus gel. Mucus transport is impaired, culminating in mucus plugging and airway obstruction—a major cause of morbidity in asthma. The polymeric mucins MUC5AC and MUC5B are integral components of airway mucus. MUC5AC and MUC5B gene expression is altered in asthma, and recent work sheds light on their contribution to asthma pathogenesis. Herein, we review our current understanding of the role of MUC5AC and MUC5B in mucus dysfunction in asthma. View Full-Text
Keywords: MUC5AC; MUC5B; asthma MUC5AC; MUC5B; asthma
Show Figures

Figure 1

MDPI and ACS Style

Bonser, L.R.; Erle, D.J. Airway Mucus and Asthma: The Role of MUC5AC and MUC5B. J. Clin. Med. 2017, 6, 112.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop