Behavioural Parameters of Circadian Rhythm Are Not Correlated with Dim Light Melatonin Onset: An Observational Study on Healthy Volunteers
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Group
2.2. Study Session
2.3. Clinical Scales and Questionnaires
2.4. Sleep Diary and Actigraphy
2.5. Determination of Melatonin and DLMO
2.6. Statistical Analysis
3. Results
3.1. Characteristic of Study Group
3.2. Clinical Scales
3.3. Relationships of DLMO with Sleep Parameters and Clinical Scales
3.4. Correlations between Sleep Parameters and Clinical Scales
3.5. Other Correlations
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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All Participants (n = 21) | Participants with Calculated DLMO (n = 12) | |
---|---|---|
Age in years | 36.2 ± 7.9 (26–54) | 36.2 ± 8.8 (26–54) |
Sex | 10 M/11 F | 6 M/6 F |
Working hours/week | 44.9 ± 8.7 (38–72) | 42.9 ± 4.5 (40–50) |
All Participants | Participants with Calculated DLMO | |||
---|---|---|---|---|
Sleep Diary (n = 20) * | Actigraphy (n = 21) | Sleep Diary (n = 11) * | Actigraphy (n = 12) | |
BT | 23:25 ± 1:28 h | - | 22:50 ± 0:50 h | - |
LTLO | 33.6 ± 41.6 min | - | 22.7 ± 11.6 min | - |
LOT | 23:52 ± 1:17 h | 23:50 ± 1:05 h | 23:23 ± 0:38 h | 23:24 ± 0:39 h |
SL | 14.2 ± 8.5 min | 12.7 ± 6.9 min | 13.9 ± 11.0 min | 13.6 ± 7.0 min |
SOn | 00:06 ± 1:18 h | 00:03 ± 1:05 h | 23:36 ± 0:43 h | 23:38 ± 0:42 h |
SOff | 07:36 ± 1:21 h | 07:30 ± 1:23 h | 07:01 ± 0:49 h | 06:54 ± 0:48 h |
TST | 419.0 ± 37.5 min | 386.8 ± 40.8 min | 419.5 ± 38.9 min | 372.8 ± 38.5 min |
SE | 87.4 ± 5.8% | 84.0 ± 3.8% | 88.0 ± 6.2% | 82.4 ± 3.8% |
LTGU | 12.3 ± 8.3 min | 6.9 ± 5.5 min | 9.6 ± 5.5 min | 7.3 ± 5.8 min |
OOBT | 07:48 ± 1:28 h | 07:37 ± 1:23 h | 07:11 ± 0:51 h | 07:01 ± 0:50 h |
SFI | - | 22.6 ± 7.7% | - | 25.0 ± 8.7% |
Clinical Scales | ||||
---|---|---|---|---|
All Participants (n = 21) | Participants with Calculated DLMO (n = 12) | |||
Mean Scores | Range | Mean Scores | Range | |
AIS | 6.1 ± 3.7 | 1–13 | 6.7 ± 4.1 | 1–13 |
ISI | 5.6 ± 5.2 | 0–16 | 5.6 ± 5.1 | 0–16 |
ESS | 8.0 ± 5.3 | 0–22 | 7.4 ± 6.3 | 0–22 |
MEQ | 50.3 ± 11.9 | 28–67 | 55.9 ± 9.5 | 49–67 |
CSM | 35.8 ± 10.8 | 15–50 | 41.0 ± 9.1 | 22–49 |
Correlation with DLMO r Coefficient | |
---|---|
Age | 0.45 |
BT (D) | 0.29 |
LOT (D) | 0.03 |
OOBT (D) | −0.03 |
TST (D) | −0.09 |
SL (D) | 0.15 |
SE (D) | 0.17 |
LTLO (D) | −0.64 * |
LTGU (D) | 0.03 |
LOT (A) | −0.08 |
SOn (A) | −0.06 |
SOff (A) | −0.10 |
TST (A) | −0.13 |
SL (A) | 0.01 |
SE (A) | −0.32 |
SFI (A) | 0.67 * |
AIS | 0.57 |
ISI | 0.60 * |
ESS | 0.61 * |
MEQ | −0.19 |
CSM | −0.11 |
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Dermanowski, M.M.; Wichniak, A.; Hejduk, A.; Kuczyńska, J.; Dominiak, M.; Mierzejewski, P. Behavioural Parameters of Circadian Rhythm Are Not Correlated with Dim Light Melatonin Onset: An Observational Study on Healthy Volunteers. J. Clin. Med. 2023, 12, 7757. https://doi.org/10.3390/jcm12247757
Dermanowski MM, Wichniak A, Hejduk A, Kuczyńska J, Dominiak M, Mierzejewski P. Behavioural Parameters of Circadian Rhythm Are Not Correlated with Dim Light Melatonin Onset: An Observational Study on Healthy Volunteers. Journal of Clinical Medicine. 2023; 12(24):7757. https://doi.org/10.3390/jcm12247757
Chicago/Turabian StyleDermanowski, Michał Mateusz, Adam Wichniak, Arkadiusz Hejduk, Julita Kuczyńska, Monika Dominiak, and Paweł Mierzejewski. 2023. "Behavioural Parameters of Circadian Rhythm Are Not Correlated with Dim Light Melatonin Onset: An Observational Study on Healthy Volunteers" Journal of Clinical Medicine 12, no. 24: 7757. https://doi.org/10.3390/jcm12247757