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Open AccessArticle

Longitudinal Changes on Optical Coherence Tomography Angiography in Retinal Vein Occlusion

1
Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, 645 N Michigan Avenue, Ste 440, Chicago, IL 60611, USA
2
School of Medicine, Vita-Salute San Raffaele University, 20132 Milan, Italy
3
Department of Ophthalmology, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy
*
Author to whom correspondence should be addressed.
This study has been presented as an abstract at the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, 29 April–3 May 2018.
Academic Editor: Fabio Scarinci
J. Clin. Med. 2021, 10(7), 1423; https://doi.org/10.3390/jcm10071423
Received: 18 February 2021 / Revised: 20 March 2021 / Accepted: 25 March 2021 / Published: 1 April 2021
Background: To evaluate the longitudinal changes on optical coherence tomography angiography (OCTA) in retinal vein occlusion (RVO). Methods: Retrospective study of patients with RVO treated with intravitreal anti-vascular endothelial growth factors (VEGF) for macular edema. Foveal avascular zone (FAZ) area, vessel density (VD), vessel length density (VLD), and adjusted flow index (AFI) were calculated. The unaffected eye of each participant was used as a control. Results: Twelve RVO eyes were included, receiving 6 ± 3 anti-VEGF injections over a follow-up of 10.4 ± 3.1 months. Compared to fellow eyes, RVO eyes had lower VD and VLD at inclusion (p = 0.07 and p = 0.04) and last visit (p = 0.002 and p < 0.001). VD, AFI, and VLD did not change over time, while FAZ area increased in RVO eyes (+0.016 ± 0.024 mm2, p = 0.04). AFI correlated with duration of disease (r = 0.63, p = 0.02). Visual acuity was inversely related to VD and VLD over the follow-up. Conclusions: OCTA parameters remained stable with sustained anti-VEGF treatment in RVO, while changes in the FAZ area may suggest capillary remodeling after RVO. View Full-Text
Keywords: retinal vein occlusion; optical coherence tomography angiography; anti-vascular endothelial growth factors; vessel density retinal vein occlusion; optical coherence tomography angiography; anti-vascular endothelial growth factors; vessel density
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MDPI and ACS Style

Tripathy, S.; Le, H.-G.; Cicinelli, M.V.; Gill, M.K. Longitudinal Changes on Optical Coherence Tomography Angiography in Retinal Vein Occlusion. J. Clin. Med. 2021, 10, 1423. https://doi.org/10.3390/jcm10071423

AMA Style

Tripathy S, Le H-G, Cicinelli MV, Gill MK. Longitudinal Changes on Optical Coherence Tomography Angiography in Retinal Vein Occlusion. Journal of Clinical Medicine. 2021; 10(7):1423. https://doi.org/10.3390/jcm10071423

Chicago/Turabian Style

Tripathy, Swetapadma; Le, Hong-Gam; Cicinelli, Maria V.; Gill, Manjot K. 2021. "Longitudinal Changes on Optical Coherence Tomography Angiography in Retinal Vein Occlusion" J. Clin. Med. 10, no. 7: 1423. https://doi.org/10.3390/jcm10071423

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