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Article

Prediction Accuracy of Serial Lung Ultrasound in COVID-19 Hospitalized Patients (Pred-Echovid Study)

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Internal Medicine Department, Infanta Leonor-Virgen de la Torre University Hospital, 28031 Madrid, Spain
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Department of Medicine, School of Medicine, Complutense University, 28040 Madrid, Spain
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Internal Medicine Department, Doce de Octubre University Hospital, 28041 Madrid, Spain
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Emergency Department, Infanta Leonor-Virgen de la Torre University Hospital, 28031 Madrid, Spain
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Emergency Department, La Paz University Hospital, 28046 Madrid, Spain
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Enfermera Isabel Zendal Emergency Hospital, 28055 Madrid, Spain
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Internal Medicine Department, Virgen del Rocío University Hospital, 41013 Sevilla, Spain
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Internal Medicine Department, Hospital Clínico San Carlos, 28040 Madrid, Spain
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Internal Medicine Department, Hospital Universitario Infanta Cristina, 28981 Parla, Madrid, Spain
*
Author to whom correspondence should be addressed.
Academic Editors: Danilo Buonsenso and Alessandra Falchi
J. Clin. Med. 2021, 10(21), 4818; https://doi.org/10.3390/jcm10214818
Received: 13 September 2021 / Revised: 10 October 2021 / Accepted: 16 October 2021 / Published: 20 October 2021
(This article belongs to the Special Issue Current Advances in Lung Ultrasound for COVID-19)
The value of serial lung ultrasound (LUS) in patients with COVID-19 is not well defined. In this multicenter prospective observational study, we aimed to assess the prognostic accuracy of serial LUS in patients admitted to hospital due to COVID-19. The serial LUS protocol included two examinations (0–48 h and 72–96 h after admission) using a 10-zones sequence, and a 0 to 5 severity score. Primary combined endpoint was death or the need for invasive mechanical ventilation. Calibration (Hosmer–Lemeshow test and calibration curves), and discrimination power (area under the ROC curve) of both ultrasound exams (SCORE1 and 2), and their difference (DIFFERENTIAL-SCORE) were performed. A total of 469 patients (54.2% women, median age 60 years) were included. The primary endpoint occurred in 51 patients (10.9%). Probability risk tertiles of SCORE1 and SCORE2 (0–11 points, 12–24 points, and ≥25 points) obtained a high calibration. SCORE-2 showed a higher discrimination power than SCORE-1 (AUC 0.72 (0.58–0.85) vs. 0.61 (0.52–0.7)). The DIFFERENTIAL-SCORE showed a higher discrimination power than SCORE-1 and SCORE-2 (AUC 0.78 (0.66–0.9)). An algorithm for clinical decision-making is proposed. Serial lung ultrasound performing two examinations during the first days of hospitalization is an accurate strategy for predicting clinical deterioration of patients with COVID-19. View Full-Text
Keywords: lung ultrasound; COVID-19; pneumonia; point-of-care ultrasound; prognosis lung ultrasound; COVID-19; pneumonia; point-of-care ultrasound; prognosis
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MDPI and ACS Style

Torres-Macho, J.; Sánchez-Fernández, M.; Arnanz-González, I.; Tung-Chen, Y.; Franco-Moreno, A.I.; Duffort-Falcó, M.; Beltrán-Romero, L.; Rodríguez-Suaréz, S.; Bernabeu-Wittel, M.; Urbano, E.; Méndez-Bailon, M.; Roque-Rojas, F.; García-Guijarro, E.; García-Casasola, G. Prediction Accuracy of Serial Lung Ultrasound in COVID-19 Hospitalized Patients (Pred-Echovid Study). J. Clin. Med. 2021, 10, 4818. https://doi.org/10.3390/jcm10214818

AMA Style

Torres-Macho J, Sánchez-Fernández M, Arnanz-González I, Tung-Chen Y, Franco-Moreno AI, Duffort-Falcó M, Beltrán-Romero L, Rodríguez-Suaréz S, Bernabeu-Wittel M, Urbano E, Méndez-Bailon M, Roque-Rojas F, García-Guijarro E, García-Casasola G. Prediction Accuracy of Serial Lung Ultrasound in COVID-19 Hospitalized Patients (Pred-Echovid Study). Journal of Clinical Medicine. 2021; 10(21):4818. https://doi.org/10.3390/jcm10214818

Chicago/Turabian Style

Torres-Macho, Juan, Marcos Sánchez-Fernández, Irene Arnanz-González, Yale Tung-Chen, Ana I. Franco-Moreno, Mercedes Duffort-Falcó, Luis Beltrán-Romero, Santiago Rodríguez-Suaréz, Máximo Bernabeu-Wittel, Elena Urbano, Manuel Méndez-Bailon, Fernando Roque-Rojas, Elena García-Guijarro, and Gonzalo García-Casasola. 2021. "Prediction Accuracy of Serial Lung Ultrasound in COVID-19 Hospitalized Patients (Pred-Echovid Study)" Journal of Clinical Medicine 10, no. 21: 4818. https://doi.org/10.3390/jcm10214818

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