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Open AccessArticle

Effects of Transanal Irrigation on Gut Microbiota in Pediatric Patients with Spina Bifida

1
Department of Urology, Jikei University School of Medicine, Tokyo 105-8471, Japan
2
Department of Urology, Tokyo Metropolitan Rehabilitation Hospital, Tokyo 131-0034, Japan
3
Department of Urology, Spinal Injuries Center, Fukuoka 820-0053, Japan
4
Consultant MD, MedDevHealth, Geelsvej, 15 2840 Holte, Denmark
5
Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2021, 10(2), 224; https://doi.org/10.3390/jcm10020224
Received: 13 December 2020 / Revised: 30 December 2020 / Accepted: 5 January 2021 / Published: 10 January 2021
(This article belongs to the Special Issue Neurogenic Bowel Dysfunction)
Recent studies using 16S rRNA-based microbiota profiling have demonstrated dysbiosis of gut microbiota in constipated patients. The aim of this study was to investigate the changes in gut microbiota after transanal irrigation (TAI) in patients with spina bifida (SB). A questionnaire on neurogenic bowel disfunction (NBD), Bristol scale, and gut microbiota using 16S rRNA sequencing were completed in 16 SB patients and 10 healthy controls aged 6–17 years. Then, 11 of 16 SB patients with moderate to severe NBD scores received TAI for 3 months. Changes in urine cultures were also examined before and after the TAI treatments. In addition, correlation of gut microbiota and Bristol scale was analyzed. Significantly decreased abundance in Faecalibacterium, Blautia and Roseburia, and significantly increased abundance in Bacteroides and Roseburia were observed in the SB patients compared with controls and after TAI, respectively. The abundance of Roseburia was significantly correlated positively with Bristol scale. Urinary tract infection tended to decrease from 82% to 55% after TAI (p = 0.082) despite persistent fecal incontinence. Butyrate-producing bacteria such as Roseburia play a regulatory role in the intestinal motility and host immune system, suggesting the effects of TAI on gut microbiota. View Full-Text
Keywords: constipation; gut microbiota; spina bifida; transanal irrigation; urinary tract infection constipation; gut microbiota; spina bifida; transanal irrigation; urinary tract infection
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MDPI and ACS Style

Furuta, A.; Suzuki, Y.; Takahashi, R.; Jakobsen, B.P.; Kimura, T.; Egawa, S.; Yoshimura, N. Effects of Transanal Irrigation on Gut Microbiota in Pediatric Patients with Spina Bifida. J. Clin. Med. 2021, 10, 224. https://doi.org/10.3390/jcm10020224

AMA Style

Furuta A, Suzuki Y, Takahashi R, Jakobsen BP, Kimura T, Egawa S, Yoshimura N. Effects of Transanal Irrigation on Gut Microbiota in Pediatric Patients with Spina Bifida. Journal of Clinical Medicine. 2021; 10(2):224. https://doi.org/10.3390/jcm10020224

Chicago/Turabian Style

Furuta, Akira; Suzuki, Yasuyuki; Takahashi, Ryosuke; Jakobsen, Birte P.; Kimura, Takahiro; Egawa, Shin; Yoshimura, Naoki. 2021. "Effects of Transanal Irrigation on Gut Microbiota in Pediatric Patients with Spina Bifida" J. Clin. Med. 10, no. 2: 224. https://doi.org/10.3390/jcm10020224

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