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Article

Clinical and Cytokine Profile in Patients with Early and Late Onset Meniere Disease

1
Otology and Neurotology Group CTS495, Department of Genomic Medicine, GENYO—Centre for Genomics and Oncological Research—Pfizer/University of Granada/Junta de Andalucía, PTS, 18016 Granada, Spain
2
Department of Otolaryngology, Instituto de Investigación Biosanitaria ibs.Granada, Hospital Universitario Virgen de las Nieves, Universidad de Granada, 18014 Granada, Spain
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Sensorineural Pathology Programme, Centro de Investigación Biomédica en Red en Enfermedades Raras, CIBERER, 28029 Madrid, Spain
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Department of Neurology, Hospital Universitario Virgen de las Nieves, Universidad de Granada, 18014 Granada, Spain
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Otoneurology Unit, Department of Otorhinolaryngology, University Hospital of Salamanca, IBSAL, 37007 Salamanca, Spain
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Department of Otorhinolaryngology, Complejo Hospitalario de Jaén, 23007 Jaen, Spain
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Department of Otolaryngology, Hospital Virgen Macarena, 41009 Sevilla, Spain
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Division of Neurotology, Department of Otorhinolaryngology, Complexo Hospitalario Universitario, 15706 Santiago de Compostela, Spain
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Department of Otolaryngology, Complexo Hospitalario de Pontevedra, 36071 Pontevedra, Spain
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Department of Surgery, Division of Otolaryngology, Facultad de Medicina, Universidad de Granada, 18006 Granada, Spain
*
Author to whom correspondence should be addressed.
M.-D.-C.M. and E.M.-G. shared co-first authorship.
L.F. and J.A.L.-E. should be considered joint senior authors.
Academic Editor: George Psillas
J. Clin. Med. 2021, 10(18), 4052; https://doi.org/10.3390/jcm10184052
Received: 5 August 2021 / Revised: 1 September 2021 / Accepted: 3 September 2021 / Published: 7 September 2021
(This article belongs to the Special Issue Hearing Disorders: Diagnosis, Management, and Future Opportunities)
Background: Meniere disease (MD) is an inner ear disorder associated with comorbidities such as autoimmune diseases or migraine. This study describes clinical and cytokine profiles in MD according to the age of onset of the condition. Methods: A cross-sectional study including 83 MD patients: 44 with early-onset MD (EOMD, <35 years old), and 39 with late-onset MD (LOMD, >50 years old), 64 patients with migraine and 55 controls was carried out. Clinical variables and cytokines levels of CCL3, CCL4, CCL18, CCL22, CXCL,1 and IL-1β were compared among the different groups. Results: CCL18 levels were higher in patients with migraine or MD than in controls. Elevated levels of IL-1β were observed in 11.4% EOMD and in 10.3% LOMD patients and these levels were not dependent on the age of individuals. EOMD had a longer duration of the disease (p = 0.004) and a higher prevalence of migraine than LOMD (p = 0.045). Conclusions: Patients with EOMD have a higher prevalence of migraine than LOMD, but migraine is not associated with any cytokine profile in patients with MD. The levels of CCL18, CCL3, and CXCL4 were different between patients with MD or migraine and controls. View Full-Text
Keywords: hearing loss; vertigo; migraine; cytokines; inflammation; vestibular disorders hearing loss; vertigo; migraine; cytokines; inflammation; vestibular disorders
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MDPI and ACS Style

Moleon, M.-D.-C.; Martinez-Gomez, E.; Flook, M.; Peralta-Leal, A.; Gallego, J.A.; Sanchez-Gomez, H.; Montilla-Ibañez, M.A.; Dominguez-Durán, E.; Soto-Varela, A.; Aran, I.; Frejo, L.; Lopez-Escamez, J.A. Clinical and Cytokine Profile in Patients with Early and Late Onset Meniere Disease. J. Clin. Med. 2021, 10, 4052. https://doi.org/10.3390/jcm10184052

AMA Style

Moleon M-D-C, Martinez-Gomez E, Flook M, Peralta-Leal A, Gallego JA, Sanchez-Gomez H, Montilla-Ibañez MA, Dominguez-Durán E, Soto-Varela A, Aran I, Frejo L, Lopez-Escamez JA. Clinical and Cytokine Profile in Patients with Early and Late Onset Meniere Disease. Journal of Clinical Medicine. 2021; 10(18):4052. https://doi.org/10.3390/jcm10184052

Chicago/Turabian Style

Moleon, Maria-Del-Carmen, Estrella Martinez-Gomez, Marisa Flook, Andreina Peralta-Leal, Juan A. Gallego, Hortensia Sanchez-Gomez, Maria A. Montilla-Ibañez, Emilio Dominguez-Durán, Andres Soto-Varela, Ismael Aran, Lidia Frejo, and Jose A. Lopez-Escamez 2021. "Clinical and Cytokine Profile in Patients with Early and Late Onset Meniere Disease" Journal of Clinical Medicine 10, no. 18: 4052. https://doi.org/10.3390/jcm10184052

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