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Article

Neuroprotective Effects of Euonymus alatus Extract on Scopolamine-Induced Memory Deficits in Mice

by 1,2,†, 1,2,†, 1,2, 3 and 1,2,*
1
School of Food Science and Biotechnology (BK21 plus), Kyungpook National University, Daegu 41566, Korea
2
Institute of Agricultural Science and Technology, Kyungpook National University, Daegu 41566, Korea
3
Forest Resources Development Institute of Gyeongsangbuk-do, Andong 36605, Korea
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Antioxidants 2020, 9(5), 449; https://doi.org/10.3390/antiox9050449
Received: 18 April 2020 / Revised: 9 May 2020 / Accepted: 20 May 2020 / Published: 22 May 2020
(This article belongs to the Special Issue Antioxidants of Natural Product)
Euonymus alatus is considered to elicit various beneficial effects against cancer, hyperglycemia, menstrual discomfort, diabetic complications, and detoxification. The young leaves of this plant are exploited as food and also utilized for traditional medicine in East Asian countries, including Korea and China. Our preliminary study demonstrated that ethanolic extract from the Euonymus alatus leaf (EAE) exhibited the strongest antioxidant enzyme-inducing activity among more than 100 kinds of edible tree leaf extracts. This study investigated whether EAE could attenuate the cognitive deficits caused by oxidative stress in mice. Oral intubation of EAE at 100 mg/kg bw or higher resulted in significant improvements to the memory and behavioral impairment induced via i.p. injection of scopolamine. Furthermore, EAE enhanced the expression levels of hippocampal neurotrophic factors such as brain-derived neurotrophic factor (BDNF) and glial cell-derived neurotrophic factor in mice, activated the Nrf2, and the downstream heme oxygenase-1 (HO-1) a quintessential antioxidant enzyme. As rutin (quercetin-3-O-rutinose) was abundantly present in EAE and free quercetin was able to induce defensive antioxidant enzymes in an Nrf2-dependent manner, our findings suggested that quercetin derived from rutin via the intestinal microflora played a significant role in the protection of the mouse hippocampus from scopolamine-induced damage through BDNF-mediated Nrf2 activation, thereby dampening cognitive decline. View Full-Text
Keywords: Euonymus alatus; antioxidant; BDNF; cognition improvement; neuroprotective; HT22 cells; animal model Euonymus alatus; antioxidant; BDNF; cognition improvement; neuroprotective; HT22 cells; animal model
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MDPI and ACS Style

Woo, Y.; Lim, J.S.; Oh, J.; Lee, J.S.; Kim, J.-S. Neuroprotective Effects of Euonymus alatus Extract on Scopolamine-Induced Memory Deficits in Mice. Antioxidants 2020, 9, 449. https://doi.org/10.3390/antiox9050449

AMA Style

Woo Y, Lim JS, Oh J, Lee JS, Kim J-S. Neuroprotective Effects of Euonymus alatus Extract on Scopolamine-Induced Memory Deficits in Mice. Antioxidants. 2020; 9(5):449. https://doi.org/10.3390/antiox9050449

Chicago/Turabian Style

Woo, Yunju, Ji Sun Lim, Jisun Oh, Jeong Soon Lee, and Jong-Sang Kim. 2020. "Neuroprotective Effects of Euonymus alatus Extract on Scopolamine-Induced Memory Deficits in Mice" Antioxidants 9, no. 5: 449. https://doi.org/10.3390/antiox9050449

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