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Article

Neuroprotective Potential of Verbascoside Isolated from Acanthus mollis L. Leaves through Its Enzymatic Inhibition and Free Radical Scavenging Ability

1
Department of Pharmacology, Faculty of Pharmacy, Seville University, C/P. García González s/n, 41012 Seville, Spain
2
Chemistry and Biochemistry Department, San Pablo-CEU University, CEU Universities, Urb. Montepríncipe, 28668 Boadilla del Monte, Madrid, Spain
3
Department of Physical Chemistry, Faculty of Pharmacy, Seville University, C/P. García González s/n, 41012 Seville, Spain
4
Pharmaceutical and Health Sciences Department, San Pablo-CEU University, CEU Universities, Urb. Montepríncipe, 28668 Boadilla del Monte, Madrid, Spain
*
Author to whom correspondence should be addressed.
Antioxidants 2020, 9(12), 1207; https://doi.org/10.3390/antiox9121207
Received: 19 October 2020 / Revised: 18 November 2020 / Accepted: 26 November 2020 / Published: 30 November 2020
(This article belongs to the Special Issue Role of Natural Antioxidants on Neuroprotection and Neuroinflammation)
The phenomenon of today’s ageing population has increased interest in the search for new active substances that delay the onset and development of neurodegenerative diseases. In this respect, the search for natural compounds, mainly phenolic compounds, with neuroprotective activity has become the focus of growing interest. Verbascoside is a phenylethanoid that has already presented several pharmacological activities. The purpose of this study is to isolate and identify verbascoside from Acanthus mollis leaves. Consequently, its neuroprotective ability through enzymatic inhibition and free radical scavenging ability has been analyzed both in vitro and in cell culture assays. The antioxidant capacity of verbascoside was evaluated in vitro through total antioxidant capacity, DPPH, OH, and O2—scavenging activity assays. The effect of verbascoside on intracellular reactive oxygen species (ROS) levels of HepG2 and SH-SY5Y cell lines was studied in normal culture and under induced oxidative stress. The inhibitory ability of the phenylethanoid against several enzymes implied in neurodegenerative diseases (tyrosinase, MAO-A, and AChE) was analyzed in vitro. Verbascoside neuroprotective activity is at least in part related to its free radical scavenging ability. The effect of verbascoside on ROS production suggests its potential in the prevention of harmful cell redox changes and in boosting neuroprotection. View Full-Text
Keywords: Acanthus mollis L.; verbascoside; neuroprotection; antioxidant; natural compounds; oxidative stress; acteoside Acanthus mollis L.; verbascoside; neuroprotection; antioxidant; natural compounds; oxidative stress; acteoside
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MDPI and ACS Style

Burgos, C.; Muñoz-Mingarro, D.; Navarro, I.; Martín-Cordero, C.; Acero, N. Neuroprotective Potential of Verbascoside Isolated from Acanthus mollis L. Leaves through Its Enzymatic Inhibition and Free Radical Scavenging Ability. Antioxidants 2020, 9, 1207. https://doi.org/10.3390/antiox9121207

AMA Style

Burgos C, Muñoz-Mingarro D, Navarro I, Martín-Cordero C, Acero N. Neuroprotective Potential of Verbascoside Isolated from Acanthus mollis L. Leaves through Its Enzymatic Inhibition and Free Radical Scavenging Ability. Antioxidants. 2020; 9(12):1207. https://doi.org/10.3390/antiox9121207

Chicago/Turabian Style

Burgos, Carmen, Dolores Muñoz-Mingarro, Inmaculada Navarro, Carmen Martín-Cordero, and Nuria Acero. 2020. "Neuroprotective Potential of Verbascoside Isolated from Acanthus mollis L. Leaves through Its Enzymatic Inhibition and Free Radical Scavenging Ability" Antioxidants 9, no. 12: 1207. https://doi.org/10.3390/antiox9121207

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