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An Aromatic Aldehyde Synthase Controls the Synthesis of Hydroxytyrosol Derivatives Present in Virgin Olive Oil
Open AccessArticle

Hydroxytyrosol Supplementation Modifies Plasma Levels of Tissue Inhibitor of Metallopeptidase 1 in Women with Breast Cancer

1
UGC de Anatomía Patológica Hospital San Cecilio de Granada, Avda. Conocimiento s/n, 18071 Granada, Spain
2
Department of Biochemistry and Molecular Biology II, Faculty of Pharmacy, University of Granada, 18071 Granada, Spain
3
Institute of Nutrition and Food Technology, Biomedical Center Research, Avda. Conocimiento s/n, 18071 Granada, Spain
4
Department of Physiology, Faculty of Pharmacy, University of Granada, 18071 Granada, Spain
5
Department of Medical Oncolgy, Jaen Hospital, 23007 Jaen, Spain
*
Author to whom correspondence should be addressed.
Antioxidants 2019, 8(9), 393; https://doi.org/10.3390/antiox8090393
Received: 1 July 2019 / Revised: 4 September 2019 / Accepted: 8 September 2019 / Published: 11 September 2019
(This article belongs to the Special Issue Antioxidants in Olive Oils)
The etiology of breast cancer can be very different. Most antineoplastic drugs are not selective against tumor cells and also affect normal cells, leading to a wide variety of adverse reactions such as the production of free radicals by altering the redox state of the organisms. Therefore, the objective of this study was to elucidate if hydroxytyrosol (HT) (an antioxidant present in extra virgin olive oil) has a chemomodulatory effect when combined with the chemotherapeutic drugs epirubicin and cyclophosphamide followed by taxanes in breast cancer patients. Changes in plasma levels of matrix metalloproteinase 9 (MMP-9) and tissue inhibitor of metalloproteinases 1 (TIMP-1) throughout the chemotherapy treatment were studied. Both molecules are involved in cell proliferation, apoptosis, neoangiogenesis, and metastasis in breast cancer patients. Women with breast cancer were divided into two groups: a group of patients receiving a dietary supplement of HT and a control group of patients receiving placebo. The results showed that the plasma levels of TIMP-1 in the group of patients receiving HT were significantly lower than those levels found in the control group after the epirubicin-cyclophosphamide chemotherapy. View Full-Text
Keywords: hydroxytyrosol; antioxidant; extra virgin olive oil; TIMP-1; MMP-9 hydroxytyrosol; antioxidant; extra virgin olive oil; TIMP-1; MMP-9
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Ramirez-Tortosa, C.; Sanchez, A.; Perez-Ramirez, C.; Quiles, J.L.; Robles-Almazan, M.; Pulido-Moran, M.; Sanchez-Rovira, P.; Ramirez-Tortosa, M. Hydroxytyrosol Supplementation Modifies Plasma Levels of Tissue Inhibitor of Metallopeptidase 1 in Women with Breast Cancer. Antioxidants 2019, 8, 393.

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