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Beneficial Effects of Alpha-Lipoic Acid on Hypertension, Visceral Obesity, UCP-1 Expression and Oxidative Stress in Zucker Diabetic Fatty Rats

1
Department of Pharmacology and Physiology, Faculty of Medicine, Université de Montréal, Montréal, QC H3C 3J7, Canada
2
Research Team “Biology, Environment and Health”, Department of Biology, Faculty of Sciences and Techniques Errachidia, Moulay Ismail University of Meknes, 52000 Errachidia, Morocco
3
Department of Medicine, Division of Endocrinology and Metabolism, McGill University Health Centre Research Institute, McGill University, Montreal, QC H4A3J1, Canada
*
Author to whom correspondence should be addressed.
Antioxidants 2019, 8(12), 648; https://doi.org/10.3390/antiox8120648
Received: 4 November 2019 / Revised: 28 November 2019 / Accepted: 11 December 2019 / Published: 16 December 2019
(This article belongs to the Special Issue Oxidative Stress in Food Additives and Other Exposomes)
Evidence suggests that oxidative stress plays a major role in the development of metabolic syndrome. This study aims to investigate whether α-lipoic acid (LA), a potent antioxidant, could exert beneficial outcomes in Zucker diabetic fatty (ZDF) rats. Male 6-week-old ZDF rats and their lean counterparts (ZL) were fed for six weeks with a standard diet or a chow diet supplemented with LA (1 g/kg feed). At 12 weeks of age, ZDF rats exhibited an increase in systolic blood pressure, epididymal fat weight per body weight, hyperglycemia, hyperinsulinemia, insulin resistance (HOMA index), adipocyte hypertrophy and a rise in basal superoxide anion (O2) production in gastrocnemius muscle and a downregulation of epididymal uncoupled protein-1 (UCP-1) protein staining. Treatment with LA prevented the development of hypertension, the rise in whole body weight and O2 production in gastrocnemius muscle, but failed to affect insulin resistance, hyperglycemia and hyperinsulinemia in ZDF rats. LA treatment resulted in a noticeable increase of pancreatic weight and a further adipocyte hypertrophy, along with a decrease in epididymal fat weight per body weight ratio associated with an upregulation of epididymal UCP-1 protein staining in ZDF rats. These findings suggest that LA was efficacious in preventing the development of hypertension, which could be related to its antioxidant properties. The anti-visceral obesity effect of LA appears to be mediated by its antioxidant properties and the induction of UCP-1 protein at the adipose tissue level in ZDF rats. Disorders of glucose metabolism appear, however, to be mediated by other unrelated mechanisms in this model of metabolic syndrome. View Full-Text
Keywords: type 2 diabetes; metabolic syndrome; insulin resistance; visceral obesity; hypertension; oxidative stress; α-lipoic acid type 2 diabetes; metabolic syndrome; insulin resistance; visceral obesity; hypertension; oxidative stress; α-lipoic acid
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El Midaoui, A.; Fantus, I.G.; Ait Boughrous, A.; Couture, R. Beneficial Effects of Alpha-Lipoic Acid on Hypertension, Visceral Obesity, UCP-1 Expression and Oxidative Stress in Zucker Diabetic Fatty Rats. Antioxidants 2019, 8, 648.

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