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The Influence of Light on Reactive Oxygen Species and NF-кB in Disease Progression

Laser Research Centre, Faculty of Health Sciences, University of Johannesburg, P.O. Box 17011, Johannesburg 2028, South Africa
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Antioxidants 2019, 8(12), 640; https://doi.org/10.3390/antiox8120640
Received: 6 November 2019 / Revised: 29 November 2019 / Accepted: 2 December 2019 / Published: 12 December 2019
(This article belongs to the Special Issue Modulators of Oxidative Stress: Chemical and Pharmacological Aspects)
Reactive oxygen species (ROS) are important secondary metabolites that play major roles in signaling pathways, with their levels often used as analytical tools to investigate various cellular scenarios. They potentially damage genetic material and facilitate tumorigenesis by inhibiting certain tumor suppressors. In diabetic conditions, substantial levels of ROS stimulate oxidative stress through specialized precursors and enzymatic activity, while minimum levels are required for proper wound healing. Photobiomodulation (PBM) uses light to stimulate cellular mechanisms and facilitate the removal of oxidative stress. Photodynamic therapy (PDT) generates ROS to induce selective tumor destruction. The regulatory roles of PBM via crosstalk between ROS and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-кB) are substantial for the appropriate management of various conditions. View Full-Text
Keywords: photobiomodulation; reactive oxygen species (ROS); nuclear factor kappa-light-chain-enhancer of activated B cells (NF-кB); cancer; diabetes; wound healing photobiomodulation; reactive oxygen species (ROS); nuclear factor kappa-light-chain-enhancer of activated B cells (NF-кB); cancer; diabetes; wound healing
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MDPI and ACS Style

Kumar Rajendran, N.; George, B.P.; Chandran, R.; Tynga, I.M.; Houreld, N.; Abrahamse, H. The Influence of Light on Reactive Oxygen Species and NF-кB in Disease Progression. Antioxidants 2019, 8, 640.

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