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Open AccessArticle

Involvement of Neutrophil Dynamics and Function in Exercise-Induced Muscle Damage and Delayed-Onset Muscle Soreness: Effect of Hydrogen Bath

1
Faculty of Sport Sciences, Waseda University, 2-579-15 Mikajima, Tokorozawa, Saitama 359-1192, Japan
2
Waseda Bioscience Research Institute in Singapore, Waseda University, Singapore 138667, Singapore
3
College of Sports Sciences, Nihon University, 3-34-1 Simouma, Setagaya, Tokyo 154-8513, Japan
4
Department of Physical Activity Research, National Institutes of Biomedical Innovation, Health and Nutrition, 1-23-1 Toyama, Shinjuku, Tokyo 162-8636, Japan
*
Author to whom correspondence should be addressed.
Antioxidants 2018, 7(10), 127; https://doi.org/10.3390/antiox7100127
Received: 29 August 2018 / Revised: 18 September 2018 / Accepted: 22 September 2018 / Published: 25 September 2018
(This article belongs to the Special Issue Exercise and Inflammation)
The purpose of this study was to investigate the involvement of neutrophil dynamics and function in exercise-induced muscle damage (EIMD) and delayed-onset muscle soreness (DOMS), and the effect of molecular hydrogen (H2) intake on these parameters. Nine healthy and active young men performed H2 and placebo bath trial in a crossover design. They carried out downhill running (−8% slope) for 30 min at a speed corresponding to 75~85% of peak oxygen uptake (VO2peak). Subsequently, they repeated bathing for 20 min per day for one week. Degree of muscle soreness (visual analogue scale: VAS), peripheral leukocyte counts, neutrophil dynamics and function, muscle damage, and inflammation markers were measured. Plasma interleukin (IL)-6 concentration was significantly correlated with peripheral neutrophil count, VAS, and serum creatine kinase activity, respectively, after downhill running. Peripheral neutrophil count and serum myoglobin concentration were also significantly correlated. Conversely, there were no effects of H2 bath. These results suggest that IL-6 may be involved in the mobilization of neutrophils into the peripheral blood and subsequent EIMD and DOMS after downhill running; however, it is not likely that H2 bath is effective for the inflammatory process that is centered on neutrophils after downhill running. View Full-Text
Keywords: downhill running; muscle damage; delayed-onset muscle soreness; molecular hydrogen; neutrophil; oxidative stress; inflammation downhill running; muscle damage; delayed-onset muscle soreness; molecular hydrogen; neutrophil; oxidative stress; inflammation
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Kawamura, T.; Suzuki, K.; Takahashi, M.; Tomari, M.; Hara, R.; Gando, Y.; Muraoka, I. Involvement of Neutrophil Dynamics and Function in Exercise-Induced Muscle Damage and Delayed-Onset Muscle Soreness: Effect of Hydrogen Bath. Antioxidants 2018, 7, 127.

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