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Antioxidants 2017, 6(4), 102; https://doi.org/10.3390/antiox6040102

In Vitro and In Vivo Antioxidant and Anti-Hyperglycemic Activities of Moroccan Oat Cultivars

1
Laboratoire de Pharmacologie et Toxicologie, équipe de Pharmacocinétique, Faculté de Médicine et Pharmacie, University Mohammed V in Rabat, BP 6203, Rabat Instituts, Rabat 10100, Morocco
2
Laboratoire de Biochimie et Neurosciences, FST, Université Hassan I, BP 577, Settat 26000, Morocco
3
Regional Office of Rabat, National Institute for Agricultural Research, P.O. Box 6570, Rabat Institutes, Rabat 10101, Morocco
4
Pharmaceutical and Toxicological Analysis Research Team, Laboratory of Pharmacology and Toxicology, Faculty of Medicine and Pharmacy, University Mohammed V, Rabat 10100, Morocco
5
Department of Analytical Chemistry, Applied Chemometrics and Molecular Modelling, CePhaR, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, B-1090 Brussels, Belgium
6
Central Laboratory of Biochemistry, Ibn Sina Hospital, Rabat 10100, Morocco
7
Comparative Anatomy Unit-URAC-49, Hassan II Agronomy and Veterinary Institute, Rabat 10101, Morocco
*
Author to whom correspondence should be addressed.
Received: 13 September 2017 / Revised: 24 October 2017 / Accepted: 24 October 2017 / Published: 6 December 2017
(This article belongs to the Special Issue Dietary Antioxidants and Prevention of Non-Communicable Diseases)
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Abstract

Improvement of oat lines via introgression is an important process for food biochemical functionality. This work aims to evaluate the protective effect of phenolic compounds from hybrid Oat line (F11-5) and its parent (Amlal) on hyperglycemia-induced oxidative stress and to establish the possible mechanisms of antidiabetic activity by digestive enzyme inhibition. Eight phenolic acids were quantified in our samples including ferulic, p-hydroxybenzoic, caffeic, salicylic, syringic, sinapic, p-coumaric and chlorogenic acids. The Oat extract (2000 mg/kg) ameliorated the glucose tolerance, decreased Fasting Blood Glucose (FBG) and oxidative stress markers, including Superoxide dismutase (SOD), Catalase (CAT), Glutathione peroxidase (GPx), Glutathione (GSH) and Malondialdehyde (MDA) in rat liver and kidney. Furthermore, Metformin and Oat intake prevented anxiety, hypercholesterolemia and atherosclerosis in diabetic rats. In vivo anti-hyperglycemic effect of Oat extracts has been confirmed by their inhibitory activities on α-amylase (723.91 μg/mL and 1027.14 μg/mL) and α-glucosidase (1548.12 μg/mL & 1803.52 μg/mL) enzymes by mean of a mixed inhibition. View Full-Text
Keywords: streptozotocin-nicotinamide; anti-hyperglycemic; hybrid Oat; digestive enzyme streptozotocin-nicotinamide; anti-hyperglycemic; hybrid Oat; digestive enzyme
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Marmouzi, I.; Karym, E.M.; Saidi, N.; Meddah, B.; Kharbach, M.; Masrar, A.; Bouabdellah, M.; Chabraoui, L.; El Allali, K.; Cherrah, Y.; Faouzi, M.E.A. In Vitro and In Vivo Antioxidant and Anti-Hyperglycemic Activities of Moroccan Oat Cultivars. Antioxidants 2017, 6, 102.

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