In the original publication, there was a mistake in Figure 1 as published. Following the publication of this article [1], it has come to the authors’ attention that the image that represents the group 40 mg FN + MTX in Figure 1D was accidentally replaced by another image that belongs to a different group from an experiment that was conducted in parallel. The authors state that the scientific conclusions are unaffected. The updated Figure 1 is shown below. This correction was approved by the Academic Editor. The original publication has also been updated.
Figure 1.
Formononetin (FN) prevents methotrexate (MTX)-induced renal dysfunction and injury. FN ameliorated serum creatinine (A) and urea (B) and renal kidney injury molecule-1 (Kim-1) (C) in MTX-administered rats. Data are mean ± SEM, (n = 6). * p < 0.05 and *** p < 0.001. (D) Photomicrographs showing the normal structure of the glomeruli (G) and renal tubules in control and FN-treated rats, and interstitial hemorrhage (black arrow), glomerular atrophy and necrosis (arrowhead), and infiltration of leukocytes (yellow arrow) in MTX-intoxicated rats. FN prevented kidney injury induced by MTX with interstitial hemorrhage (black arrow) observed at the 10 mg/kg dose (hematoxylin and eosin (H&E); X400) [Scale bar = 50 µm].
Reference
- Aladaileh, S.H.; Hussein, O.E.; Abukhalil, M.H.; Saghir, S.A.M.; Bin-Jumah, M.; Alfwuaires, M.A.; Germoush, M.O.; Almaiman, A.A.; Mahmoud, A.M. Formononetin Upregulates Nrf2/HO-1 Signaling and Prevents Oxidative Stress, Inflammation, and Kidney Injury in Methotrexate-Induced Rats. Antioxidants 2019, 8, 430. [Google Scholar] [CrossRef] [PubMed]
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