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Oxidative Stress in the Pathogenesis of Aorta Diseases as a Source of Potential Biomarkers and Therapeutic Targets, with a Particular Focus on Ascending Aorta Aneurysms

1
Department of Cardiac Surgery, Tor Vergata University Hospital, 00133 Rome, Italy
2
Bristol Heart Institute, University of Bristol, Bristol BS2 8HW, UK
3
Department of Biomedicine, Neuroscience and Advanced Diagnostics (Bi.N.D.), University of Palermo, 90134 Palermo, Italy
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: John W. Calvert
Antioxidants 2022, 11(2), 182; https://doi.org/10.3390/antiox11020182
Received: 18 November 2021 / Revised: 6 January 2022 / Accepted: 12 January 2022 / Published: 18 January 2022
(This article belongs to the Special Issue Biomarkers of Oxidative Stress in Acute and Chronic Diseases)
Aorta diseases, such as ascending aorta aneurysm (AsAA), are complex pathologies, currently defined as inflammatory diseases with a strong genetic susceptibility. They are difficult to manage, being insidious and silent pathologies whose diagnosis is based only on imaging data. No diagnostic and prognostic biomarkers or markers of outcome have been known until now. Thus, their identification is imperative. Certainly, a deep understanding of the mechanisms and pathways involved in their pathogenesis might help in such research. Recently, the key role of oxidative stress (OS) on the pathophysiology of aorta disease has emerged. Here, we describe and discuss these aspects by revealing some OS pathways as potential biomarkers, their underlying limitations, and potential solutions and approaches, as well as some potential treatments. View Full-Text
Keywords: aorta diseases; ascending aorta aneurysm (AsAA); reactive oxygen species (ROS); oxidative stress; potential biomarkers; benefits and limitations; potential treatments aorta diseases; ascending aorta aneurysm (AsAA); reactive oxygen species (ROS); oxidative stress; potential biomarkers; benefits and limitations; potential treatments
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MDPI and ACS Style

Pisano, C.; Benedetto, U.; Ruvolo, G.; Balistreri, C.R. Oxidative Stress in the Pathogenesis of Aorta Diseases as a Source of Potential Biomarkers and Therapeutic Targets, with a Particular Focus on Ascending Aorta Aneurysms. Antioxidants 2022, 11, 182. https://doi.org/10.3390/antiox11020182

AMA Style

Pisano C, Benedetto U, Ruvolo G, Balistreri CR. Oxidative Stress in the Pathogenesis of Aorta Diseases as a Source of Potential Biomarkers and Therapeutic Targets, with a Particular Focus on Ascending Aorta Aneurysms. Antioxidants. 2022; 11(2):182. https://doi.org/10.3390/antiox11020182

Chicago/Turabian Style

Pisano, Calogera, Umberto Benedetto, Giovanni Ruvolo, and Carmela R. Balistreri. 2022. "Oxidative Stress in the Pathogenesis of Aorta Diseases as a Source of Potential Biomarkers and Therapeutic Targets, with a Particular Focus on Ascending Aorta Aneurysms" Antioxidants 11, no. 2: 182. https://doi.org/10.3390/antiox11020182

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