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Article

A Unique Acylated Flavonol Glycoside from Prunus persica (L.) var. Florida Prince: A New Solid Lipid Nanoparticle Cosmeceutical Formulation for Skincare

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Department of Pharmacognosy, Faculty of Pharmacy, October University of Modern Sciences and Arts (MSA), Giza 12451, Egypt
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Department of Biochemistry, Faculty of Pharmacy, October University for Modern Sciences and Arts (MSA), Giza 12451, Egypt
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Department of Pharmaceutics, Faculty of Pharmacy, October University of Modern Sciences and Arts (MSA), Giza 12451, Egypt
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Department of Pharmacology, Faculty of Pharmacy, October University for Modern Sciences and Arts (MSA), Giza 12451, Egypt
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National Research Centre, Department of Phytochemistry, Dokki, Cairo 12622, Egypt
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Department of Pharmacognosy, Faculty of Pharmacy, The British University in Egypt (BUE), Cairo 11837, Egypt
*
Authors to whom correspondence should be addressed.
Academic Editor: Yong Chool Boo
Antioxidants 2021, 10(3), 436; https://doi.org/10.3390/antiox10030436
Received: 24 February 2021 / Revised: 6 March 2021 / Accepted: 8 March 2021 / Published: 12 March 2021
(This article belongs to the Special Issue Phenolics as Antioxidant Agents)
Polyphenols are known dietary antioxidants. They have recently attracted considerable interest in uses to prevent skin aging and hyperpigmentation resulting from solar UV-irradiation. Prunus persica (L.) leaves are considered by-products and were reported to have a remarkable antioxidant activity due to their high content of polyphenols. This study aimed at the development of a cosmeceutical anti-aging and skin whitening cream preparation using ethanol leaves extract of Prunus persica (L.) (PPEE) loaded in solid lipid nanoparticles (SLNs) to enhance the skin delivery. Chemical investigation of PPEE showed significantly high total phenolic and flavonoids content with notable antioxidant activities (DPPH, ABTS, and β-carotene assays). A unique acylated kaempferol glycoside with a rare structure, kaempferol 3-O-β-4C1-(6″-O-3,4-dihydroxyphenylacetyl glucopyranoside) (KDPAG) was isolated for the first time and its structure fully elucidated. It represents the first example of acylation with 3,4-dihydroxyphenyl acetic acid in flavonoid chemistry. The in-vitro cytotoxicity studies against a human keratinocytes cell line revealed the non-toxicity of PPEE and PPEE-SLNs. Moreover, PPEE, PPEE-SLNs, and KDPAG showed good anti-elastase activity, comparable to that of N-(Methoxysuccinyl)-Ala-Ala-Pro-Val-chloromethyl ketone. Besides, PPEE-SLNs and KDPAG showed significantly (p < 0.001) higher anti-collagenase and anti-tyrosinase activities in comparison to EDTA and kojic acid, respectively. Different PPEE-SLNs cream formulae (2% and 5%) were evaluated for possible anti-wrinkle activity against UV-induced photoaging in a mouse model using a wrinkle scoring method and were shown to offer a highly significant protective effect against UV, as evidenced by tissue biomarkers (SOD) and histopathological studies. Thus, the current study demonstrates that Prunus persica leaf by-products provide an interesting, valuable resource for natural cosmetic ingredients. This provides related data for further studying the potential safe use of PPEE-SLNs in topical anti-aging cosmetic formulations with enhanced skin permeation properties. View Full-Text
Keywords: kaempferol 3-O-β-4C1-(6″-O-3,4-dihydroxyphenylacetyl glucopyranoside) by-products; solid lipid nanoparticles; antioxidant; in-vitro skin related enzymes; in-vivo anti-wrinkle kaempferol 3-O-β-4C1-(6″-O-3,4-dihydroxyphenylacetyl glucopyranoside) by-products; solid lipid nanoparticles; antioxidant; in-vitro skin related enzymes; in-vivo anti-wrinkle
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MDPI and ACS Style

Mostafa, E.S.; Maher, A.; Mostafa, D.A.; Gad, S.S.; Nawwar, M.A.M.; Swilam, N. A Unique Acylated Flavonol Glycoside from Prunus persica (L.) var. Florida Prince: A New Solid Lipid Nanoparticle Cosmeceutical Formulation for Skincare. Antioxidants 2021, 10, 436. https://doi.org/10.3390/antiox10030436

AMA Style

Mostafa ES, Maher A, Mostafa DA, Gad SS, Nawwar MAM, Swilam N. A Unique Acylated Flavonol Glycoside from Prunus persica (L.) var. Florida Prince: A New Solid Lipid Nanoparticle Cosmeceutical Formulation for Skincare. Antioxidants. 2021; 10(3):436. https://doi.org/10.3390/antiox10030436

Chicago/Turabian Style

Mostafa, Eman S., Ahmed Maher, Dalia A. Mostafa, Sameh S. Gad, Mahmoud A.M. Nawwar, and Noha Swilam. 2021. "A Unique Acylated Flavonol Glycoside from Prunus persica (L.) var. Florida Prince: A New Solid Lipid Nanoparticle Cosmeceutical Formulation for Skincare" Antioxidants 10, no. 3: 436. https://doi.org/10.3390/antiox10030436

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