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Article

Rebaudioside A Enhances Resistance to Oxidative Stress and Extends Lifespan and Healthspan in Caenorhabditis elegans

by 1,2, 1,2, 1,3,* and 1,2,*
1
State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
2
University of Chinese Academy of Sciences, Beijing 100049, China
3
LipidALL Technologies Company Limited, Changzhou 213022, Jiangsu, China
*
Authors to whom correspondence should be addressed.
Academic Editors: Chiara Nediani and Monica Dinu
Antioxidants 2021, 10(2), 262; https://doi.org/10.3390/antiox10020262
Received: 2 January 2021 / Revised: 29 January 2021 / Accepted: 2 February 2021 / Published: 8 February 2021
Non-nutritive sweeteners are widely used in food and medicines to reduce energy content without compromising flavor. Herein, we report that Rebaudioside A (Reb A), a natural, non-nutritive sweetener, can extend both the lifespan and healthspan of C. elegans. The beneficial effects of Reb A were principally mediated via reducing the level of cellular reactive oxygen species (ROS) in response to oxidative stress and attenuating neutral lipid accumulation with aging. Transcriptomics analysis presented maximum differential expression of genes along the target of rapamycin (TOR) signaling pathway, which was further confirmed by quantitative real-time PCR (qPCR); while lipidomics uncovered concomitant reductions in the levels of phosphatidic acids (PAs), phosphatidylinositols (PIs) and lysophosphatidylcholines (LPCs) in worms treated with Reb A. Our results suggest that Reb A attenuates aging by acting as effective cellular antioxidants and also in lowering the ectopic accumulation of neutral lipids. View Full-Text
Keywords: C. elegans; non-nutritive sweetener; rebaudioside A; aging; oxidative stress resistance; TOR; lipidomics C. elegans; non-nutritive sweetener; rebaudioside A; aging; oxidative stress resistance; TOR; lipidomics
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MDPI and ACS Style

Li, P.; Wang, Z.; Lam, S.M.; Shui, G. Rebaudioside A Enhances Resistance to Oxidative Stress and Extends Lifespan and Healthspan in Caenorhabditis elegans. Antioxidants 2021, 10, 262. https://doi.org/10.3390/antiox10020262

AMA Style

Li P, Wang Z, Lam SM, Shui G. Rebaudioside A Enhances Resistance to Oxidative Stress and Extends Lifespan and Healthspan in Caenorhabditis elegans. Antioxidants. 2021; 10(2):262. https://doi.org/10.3390/antiox10020262

Chicago/Turabian Style

Li, Pan, Zehua Wang, Sin M. Lam, and Guanghou Shui. 2021. "Rebaudioside A Enhances Resistance to Oxidative Stress and Extends Lifespan and Healthspan in Caenorhabditis elegans" Antioxidants 10, no. 2: 262. https://doi.org/10.3390/antiox10020262

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