Table of Contents
Brain Sci., Volume 8, Issue 11 (November 2018)
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Cover Story (view full-size image) Movement disorders are common features of metal storage disorders. The current study investigates [...] Read more. Movement disorders are common features of metal storage disorders. The current study investigates the prevalence of Parkinsonism in these rare inherited disorders, with an aim to better understand the pathophysiology of idiopathic Parkinson’s Disease, through identifying and comparing the features seen in these patients to the typical presentation of Parkinson’s. The cover image shows the eye of a patient with Wilson’s Disease, one of the more common metal storage disorders, displaying the characteristic Kayser-Fleischer rings outlining the iris, caused by deposition of copper. In the pupil is a diagram of the basal ganglia, which are affected in Parkinsonism. The cover image also acts as a metaphor for taking a closer look at the pathological mechanisms in idiopathic Parkinson’s Disease. View this paper