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Brain Sciences, Volume 8, Issue 11

November 2018 - 12 articles

Cover Story: Movement disorders are common features of metal storage disorders. The current study investigates the prevalence of Parkinsonism in these rare inherited disorders, with an aim to better understand the pathophysiology of idiopathic Parkinson’s Disease, through identifying and comparing the features seen in these patients to the typical presentation of Parkinson’s. The cover image shows the eye of a patient with Wilson’s Disease, one of the more common metal storage disorders, displaying the characteristic Kayser-Fleischer rings outlining the iris, caused by deposition of copper. In the pupil is a diagram of the basal ganglia, which are affected in Parkinsonism. The cover image also acts as a metaphor for taking a closer look at the pathological mechanisms in idiopathic Parkinson’s Disease. View this paper
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Articles (12)

  • Review
  • Open Access
48 Citations
6,951 Views
16 Pages

New Hope in Brain Glioma Surgery: The Role of Intraoperative Ultrasound. A Review

  • Maria Angela Pino,
  • Alessia Imperato,
  • Irene Musca,
  • Rosario Maugeri,
  • Giuseppe Roberto Giammalva,
  • Gabriele Costantino,
  • Francesca Graziano,
  • Francesco Meli,
  • Natale Francaviglia and
  • Domenico Gerardo Iacopino
  • + 1 author

19 November 2018

Maximal safe resection represents the gold standard for surgery of malignant brain tumors. As regards gross-total resection, accurate localization and precise delineation of the tumor margins are required. Intraoperative diagnostic imaging (Intra-Ope...

  • Review
  • Open Access
36 Citations
26,948 Views
11 Pages

18 November 2018

Borderline personality disorder (BPD) is a chronic psychiatric disorder characterized by pervasive affective instability, self-image disturbances, impulsivity, marked suicidality, and unstable interpersonal relationships as the core dimensions of psy...

  • Article
  • Open Access
27 Citations
11,881 Views
24 Pages

EEG Waveform Analysis of P300 ERP with Applications to Brain Computer Interfaces

  • Rodrigo Ramele,
  • Ana Julia Villar and
  • Juan Miguel Santos

16 November 2018

The Electroencephalography (EEG) is not just a mere clinical tool anymore. It has become the de-facto mobile, portable, non-invasive brain imaging sensor to harness brain information in real time. It is now being used to translate or decode brain sig...

  • Review
  • Open Access
14 Citations
12,006 Views
15 Pages

16 November 2018

Diffuse intrinsic pontine glioma (DIPG) is a devastating and incurable paediatric brain tumour with a median overall survival of 9 months. Until recently, DIPGs were treated similarly to adult gliomas, but due to the advancement in molecular and imag...

  • Article
  • Open Access
37 Citations
8,027 Views
14 Pages

The Multiple Hit Hypothesis for Gulf War Illness: Self-Reported Chemical/Biological Weapons Exposure and Mild Traumatic Brain Injury

  • Patricia Janulewicz,
  • Maxine Krengel,
  • Emily Quinn,
  • Timothy Heeren,
  • Rosemary Toomey,
  • Ronald Killiany,
  • Clara Zundel,
  • Joy Ajama,
  • James O’Callaghan and
  • Lea Steele
  • + 2 authors

13 November 2018

The Gulf War Illness Consortium (GWIC) was designed to identify objective biomarkers of Gulf War Illness (GWI) in 1991 Gulf War veterans. The symptoms of GWI include fatigue, pain, cognitive problems, gastrointestinal, respiratory, and skin problems....

  • Article
  • Open Access
31 Citations
5,591 Views
9 Pages

Use and Propensity to Use Substances as Cognitive Enhancers in Italian Medical Students

  • Marcella Pighi,
  • Giancarlo Pontoni,
  • Arianna Sinisi,
  • Silvia Ferrari,
  • Giorgio Mattei,
  • Luca Pingani,
  • Elena Simoni and
  • Gian Maria Galeazzi

9 November 2018

International media has paid attention to the use of substances by healthy subjects to enhance cognitive performance. Medical students are liable to use cognitive enhancers (CE) with the aim of improving academic performance. The study explored use a...

  • Article
  • Open Access
8 Citations
4,889 Views
11 Pages

Opposing Morphogenetic Defects on Dendrites and Mossy Fibers of Dentate Granular Neurons in CRMP3-Deficient Mice

  • Tam T. Quach,
  • Nathalie Auvergnon,
  • Rajesh Khanna,
  • Marie-Françoise Belin,
  • Papachan E. Kolattukudy,
  • Jérome Honnorat and
  • Anne-Marie Duchemin

3 November 2018

Collapsin response mediator proteins (CRMPs) are highly expressed in the brain during early postnatal development and continue to be present in specific regions into adulthood, especially in areas with extensive neuronal plasticity including the hipp...

  • Article
  • Open Access
6 Citations
3,303 Views
9 Pages

The Duration of Emotional Image Exposure Does Not Impact Anticipatory Postural Adjustments during Gait Initiation

  • Thierry Gélat,
  • Laure Coudrat,
  • Carole Ferrel-Chapus and
  • Sylvie Vernazza-Martin

1 November 2018

Previous studies have reported that anticipatory postural adjustments (APAs) associated with gait initiation are affected by emotion-eliciting images. This study examined the effect of the duration of exposure to emotional images on the APAs along th...

  • Review
  • Open Access
5 Citations
5,851 Views
15 Pages

Parkinson’s Disease and Metal Storage Disorders: A Systematic Review

  • Edward Botsford,
  • Jayan George and
  • Ellen E. Buckley

31 October 2018

Metal storage disorders (MSDs) are a set of rare inherited conditions with variable clinical pictures including neurological dysfunction. The objective of this study was, through a systematic review, to identify the prevalence of Parkinsonism in pati...

  • Article
  • Open Access
78 Citations
7,922 Views
10 Pages

29 October 2018

Background. According to the Minorities’ Diminished Returns (MDR) theory, the health returns of socioeconomic status (SES) are systemically smaller for Blacks compared to Whites. Less is known, however, about trans-generational aspects of such dimini...

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Brain Sci. - ISSN 2076-3425