Next Article in Journal
Proposal for a Methodology Based on XRD and SEM-EDS to Monitor Effects of Lime-Treatment on Clayey Soils
Next Article in Special Issue
Effects of Infusion and Storage on Antioxidant Activity and Total Phenolic Content of Black Tea
Previous Article in Journal
Kinematic and Dynamic Modelling for a Class of Hybrid Robots Composed of m Local Closed-Loop Linkages Appended to an n-Link Serial Manipulator
Previous Article in Special Issue
Evaluation of Antioxidant Activity, Toxicity, and Phenolic Profile of Aqueous Extracts of Chamomile (Matricaria chamomilla L.) and Sage (Salvia officinalis L.) Prepared at Different Temperatures
Article

Antiphotoaging Effect of (2′S)-Columbianetin from Corydalis heterocarpa in UVA-Irradiated Human Dermal Fibroblasts

1
Marine Biotechnology Center for Pharmaceuticals and Foods, College of Medical and Life Sciences, Silla University, Busan 46958, Korea
2
Department of Food and Nutrition, College of Medical and Life Sciences, Silla University, Busan 46958, Korea
3
Department of Convergence Study on the Ocean Science and Technology, Ocean Science and Technology School, Korea Maritime and Ocean University, Busan 49112, Korea
*
Author to whom correspondence should be addressed.
Appl. Sci. 2020, 10(7), 2568; https://doi.org/10.3390/app10072568
Received: 10 February 2020 / Revised: 30 March 2020 / Accepted: 1 April 2020 / Published: 9 April 2020
(This article belongs to the Special Issue Antioxidants in Natural Products)
Ultraviolet A (UVA)-induced detrimental effects in the skin, also known as photoaging, are mediated with several pathways including oxidative stress generation and extracellular matrix (ECM) degradation. UVA irradiation results in excessive production of matrix metalloproteinases (MMPs), enzymes responsible for the degradation of ECM components such as collagen. In this study, the protective effects of (2′S)-columbianetin against UVA-induced changes in matrix metalloproteinase-1 (MMP-1) and collagen production were investigated in human dermal fibroblasts (HDFs). The (2′S)-columbianetin was isolated from Corydalis heterocarpa. UVA exposure increased MMP-1 release from HDFs and diminished the release of type I pro-collagen. Treatment with (2′S)-columbianetin reversed these effects of UVA exposure. The (2′S)-columbianetin treatment also suppressed the intracellular expression of MMP-1 and increased type I pro-collagen expression. UVA exposure elevated the activation of p38, c-Jun-amino-terminal kinase (JNK) and extracellular signal-related kinase (ERK) as the mechanism to stimulate MMP-1 production. The (2′S)-columbianetin suppressed the phosphorylation of JNK and ERK. The (2′S)-columbianetin was also stimulated collagen production via TGFβ signaling cascade, relieving UVA-induced suppression of Smad2/3 phosphorylation and translocation. In conclusion, (2′S)-columbianetin was suggested to be a potential cosmeceutical lead compound with antiphotoaging properties against UVA-induced collagen degradation. View Full-Text
Keywords: columbianetin; human dermal fibroblast; MAPK; photoaging; TGFβ; UVA columbianetin; human dermal fibroblast; MAPK; photoaging; TGFβ; UVA
Show Figures

Figure 1

MDPI and ACS Style

Oh, J.H.; Karadeniz, F.; Lee, J.I.; Kim, H.R.; Seo, Y.; Kong, C.-S. Antiphotoaging Effect of (2′S)-Columbianetin from Corydalis heterocarpa in UVA-Irradiated Human Dermal Fibroblasts. Appl. Sci. 2020, 10, 2568. https://doi.org/10.3390/app10072568

AMA Style

Oh JH, Karadeniz F, Lee JI, Kim HR, Seo Y, Kong C-S. Antiphotoaging Effect of (2′S)-Columbianetin from Corydalis heterocarpa in UVA-Irradiated Human Dermal Fibroblasts. Applied Sciences. 2020; 10(7):2568. https://doi.org/10.3390/app10072568

Chicago/Turabian Style

Oh, Jung H., Fatih Karadeniz, Jung I. Lee, Hye R. Kim, Youngwan Seo, and Chang-Suk Kong. 2020. "Antiphotoaging Effect of (2′S)-Columbianetin from Corydalis heterocarpa in UVA-Irradiated Human Dermal Fibroblasts" Applied Sciences 10, no. 7: 2568. https://doi.org/10.3390/app10072568

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop