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Optics Based Label-Free Techniques and Applications in Brain Monitoring

Research Unit of Medical Imaging, Physics and Technology, Faculty of Medicine, University of Oulu, 90220 Oulu, Finland
Optoelectronics and Measurement Techniques Research Unit, Faculty of Information Technology and Electrical Engineering, University of Oulu, 90570 Oulu, Finland
Author to whom correspondence should be addressed.
Appl. Sci. 2020, 10(6), 2196;
Received: 6 February 2020 / Revised: 17 March 2020 / Accepted: 19 March 2020 / Published: 24 March 2020
(This article belongs to the Special Issue Optics and the Brain)
Functional near-infrared spectroscopy (fNIRS) has been utilized already around three decades for monitoring the brain, in particular, oxygenation changes in the cerebral cortex. In addition, other optical techniques are currently developed for in vivo imaging and in the near future can be potentially used more in human brain research. This paper reviews the most common label-free optical technologies exploited in brain monitoring and their current and potential clinical applications. Label-free tissue monitoring techniques do not require the addition of dyes or molecular contrast agents. The following optical techniques are considered: fNIRS, diffuse correlations spectroscopy (DCS), photoacoustic imaging (PAI) and optical coherence tomography (OCT). Furthermore, wearable optical brain monitoring with the most common applications is discussed. View Full-Text
Keywords: fNIRS; DCS; photoacoustic imaging; OCT; wearable brain monitoring fNIRS; DCS; photoacoustic imaging; OCT; wearable brain monitoring
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Karthikeyan, P.; Moradi, S.; Ferdinando, H.; Zhao, Z.; Myllylä, T. Optics Based Label-Free Techniques and Applications in Brain Monitoring. Appl. Sci. 2020, 10, 2196.

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