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Open AccessArticle

Antihypertensive Effect of Amaranth Hydrolysate Is Comparable to the Effect of Low-Intensity Physical Activity

1
Nutritional Sciences Academic Unit, University of Sinaloa, Culiacán, Sinaloa 80010, Mexico
2
Health Sciences Doctorate Program, Department of Chemical and Biological Sciences, University of Sonora, Hermosillo, Sonora 83000, Mexico
3
Center of Research and Teaching in Health Sciences (CIDOCS), Autonomous University of Sinaloa, Culiacán, Sinaloa 80030, Mexico
4
Nutrition, Research Center for Food and Development, CIAD, A.C. Carretera a La Victoria Km. 0.6, Hermosillo, Sonora 83304, Mexico
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Sports and Physical Education Faculty, Laboratory of Prescription of Physical Exercise for Health, University of Sinaloa, Culiacán, Sinaloa 80013, Mexico
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Division of Sciences and Engineering, Department of Chemical, Biological and Agricultural Sciences, Clinical and Research Laboratory (LACIUS, URS), University of Sonora, Navojoa, Sonora 85880, Mexico
*
Authors to whom correspondence should be addressed.
Appl. Sci. 2020, 10(16), 5706; https://doi.org/10.3390/app10165706
Received: 18 July 2020 / Revised: 13 August 2020 / Accepted: 13 August 2020 / Published: 17 August 2020
(This article belongs to the Special Issue Research of Bioactive Peptides in Foods)
Background and objectives: Both antihypertensive peptide intake and physical activity help to control blood pressure. Our aim was to evaluate the impact of consuming amaranth antihypertensive peptides on systolic blood pressure (SBP) in normotensive rats and the magnitude and relevance of the peptide-induced antihypertensive effect in spontaneously hypertensive rats (SHR). Materials and Methods: Treatments (alcalase-generated amaranth protein hydrolysate, captopril, or water) were given by gavage and the SBP measured by the tail-cuff method. Physical activity was performed five days/week (for twenty weeks). Results: The normotensive rats’ SBP (mmHg, average/group) remained unaffected after amaranth antihypertensive peptide supplementation (121.8) (p > 0.05 vs controls). In SHR, the SBP was lowered by 24.6 (sedentary/supplemented at two weeks), 42.0 (sedentary/supplemented at eight weeks), and 31.5 (exercised/non-supplemented at eight weeks) (p < 0.05 vs sedentary/non-supplemented). The combination of supplementation and physical activity lowered the SBP by 36.2 and 42.7 (supplemented/exercised at two weeks and eight weeks, respectively) (p < 0.05 vs sedentary/non-supplemented), but it did not have additional antihypertensive benefits (p > 0.05 vs sedentary/supplemented at eight weeks or exercised/non-supplemented at eight weeks). Conclusions: Amaranth antihypertensive peptide supplementation has no impact on SBP in normotensive rats. This supplementation develops sustained antihypertensive benefits in SHR, which are similar to the antihypertensive effect developed after eight- or twenty-week low-intensity physical activity. These findings have implications for developing safe and effective peptide-based functional foods. View Full-Text
Keywords: amaranth hydrolysate; physical activity; ACE-1; hydrolysis amaranth hydrolysate; physical activity; ACE-1; hydrolysis
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Cabrera-Chávez, F.; Lopez-Teros, V.; Gutiérrez-Arzapalo, P.Y.; Cárdenas-Torres, F.I.; Rios-Burgueño, E.R.; Astiazaran-Garcia, H.; Murúa, J.A.H.; González-Ochoa, G.; Ramírez-Torres, G.I.; Ontiveros, N. Antihypertensive Effect of Amaranth Hydrolysate Is Comparable to the Effect of Low-Intensity Physical Activity. Appl. Sci. 2020, 10, 5706.

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