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Behav. Sci. 2018, 8(10), 87; https://doi.org/10.3390/bs8100087

Rotating and Neurochemical Activity of Rats Lesioned with Quinolinic Acid and Transplanted with Bone Marrow Mononuclear Cells

1
Immunochemical Department, International Center for Neurological Restoration, 25th Ave, Playa, 15805, Havana PC 11300, Cuba
2
Experimental Neurophysiology Department, International Center of Neurological Restoration (CIREN) Ave. 25 No. 15805 e/158 and 160, Playa, Havana 11300, Cuba
3
Molecular biology Department, International Center of Neurological Restoration (CIREN) Ave. 25 No. 15805 e/158 and 160, Playa, Havana 11300, Cuba
4
Policlínico 26 de Julio, Calle 72 #1313. A. Almendares, Playa, Havana 11300, Cuba
*
Author to whom correspondence should be addressed.
Received: 10 August 2018 / Revised: 11 September 2018 / Accepted: 17 September 2018 / Published: 20 September 2018
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Abstract

Huntington’s disease (HD) is an inherited, neurodegenerative disorder that results from the degeneration of striatal neurons, mainly GABAergic neurons. The study of neurochemical activity has provided reliable markers to explain motor disorders. To treat neurodegenerative diseases, stem cell transplants with bone marrow (BM) have been performed for several decades. In this work we determine the effect of mononuclear bone marrow cell (mBMC) transplantation on the rotational behavior and neurochemical activity in a model of Huntington’s disease in rats. Four experimental groups were organized: Group I: Control animals (n = 5); Group II: Lesion with quinolinic acid (QA) in the striatum (n = 5); Group III: Lesion with QA and transplant with mBMC (n = 5); Group IV: Lesion with QA and transplant with culture medium (Dulbecco’s modified Eagle’s medium (DMEM) injection) (n = 5). The rotational activity induced by D-amphetamine was evaluated and the concentration of the neurotransmitter amino acids (glutamate and GABA) was studied. The striatal cell transplantation decreases the rotations induced by D-amphetamine (p < 0.04, Wilcoxon matched pairs test) and improves the changes produced in the levels of neurotransmitters studied. This work suggests that the loss of GABAergic neurons in the brain of rats lesioned with AQ produces behavioral and neurochemical alterations that can be reversed with the use of bone marrow mononuclear cell transplants. View Full-Text
Keywords: striatum; quinolinic acid; transplantation; mononuclear cell; bone marrow cell; Huntington disease model striatum; quinolinic acid; transplantation; mononuclear cell; bone marrow cell; Huntington disease model
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Serrano Sánchez, T.; González Fraguela, M.E.; Blanco Lezcano, L.; Alberti Amador, E.; Caballero Fernández, B.; Robinson Agramonte, M.D.Á.; Lorigados Pedre, L.; Bergado Rosado, J.A. Rotating and Neurochemical Activity of Rats Lesioned with Quinolinic Acid and Transplanted with Bone Marrow Mononuclear Cells. Behav. Sci. 2018, 8, 87.

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