Ejaculatory and Orgasmic Dysfunction Following Prostate Cancer Therapy: Clinical Management
Abstract
:1. Introduction
2. Definition of Orgasm
3. Premature Ejaculation
3.1. Behavioral Therapy
3.2. Topical Anesthetics
3.3. Systemic Therapy
3.4. Other Therapies
4. Anorgasmia/Anejaculation
5. Climacturia
6. Painful Orgasm/Dysorgasmia
7. Discussion
Funding
Conflicts of Interest
References
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Drug | Description | Side Effects |
---|---|---|
SSRI (dapoxetine, citalopram, fluoxetine, fluvoxamine, paroxetine, sertraline) | Activation of 5-HT receptors have inhibitory effects on ejaculation pathway | Reduced libido, mild headache, nausea, sweating and dizziness |
SNRI | Increase 5-HT and norepinephrine in synaptic cleft resulting in inhibition of ejaculation pathway | Reduced libido, mild headache, nausea, sweating and dizziness |
TCA (clomipramine) | Block the reuptake of both norepinephrine and serotonin and therefore are thought to work in a similar manner to SNRIs | dizziness, confusion, difficulty urinating, and dry mouth |
Tramadol | Neuromodulation of central 5-HT and norepinephrine | Potential for abuse and dependency, constipation, dizziness, nausea, vertigo, headache |
Topical Anesthetic | Decrease hypersensitivity to penile stimulation | Burning, erythema, changes in skin color |
Behavioral Therapy | Improved control over orgasm response | minimal |
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Green, T.P.; Saavedra-Belaunde, J.; Wang, R. Ejaculatory and Orgasmic Dysfunction Following Prostate Cancer Therapy: Clinical Management. Med. Sci. 2019, 7, 109. https://doi.org/10.3390/medsci7120109
Green TP, Saavedra-Belaunde J, Wang R. Ejaculatory and Orgasmic Dysfunction Following Prostate Cancer Therapy: Clinical Management. Medical Sciences. 2019; 7(12):109. https://doi.org/10.3390/medsci7120109
Chicago/Turabian StyleGreen, Travis P., Jose Saavedra-Belaunde, and Run Wang. 2019. "Ejaculatory and Orgasmic Dysfunction Following Prostate Cancer Therapy: Clinical Management" Medical Sciences 7, no. 12: 109. https://doi.org/10.3390/medsci7120109
APA StyleGreen, T. P., Saavedra-Belaunde, J., & Wang, R. (2019). Ejaculatory and Orgasmic Dysfunction Following Prostate Cancer Therapy: Clinical Management. Medical Sciences, 7(12), 109. https://doi.org/10.3390/medsci7120109