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Med. Sci. 2018, 6(1), 16; https://doi.org/10.3390/medsci6010016

Narcolepsy and Psychiatric Disorders: Comorbidities or Shared Pathophysiology?

1
Division of Child Neurology and Sleep Medicine, Geisinger Medical Center, Danville, PA 17820, USA
2
Division of Pediatric Neurology, Pediatric Sleep Program (Neurology), Department of Pediatrics, Cohen Children’s Medical Center, Lake Success, NY 11042, USA
*
Author to whom correspondence should be addressed.
Received: 3 January 2018 / Revised: 2 February 2018 / Accepted: 6 February 2018 / Published: 15 February 2018
(This article belongs to the Special Issue Updates in Pediatric Sleep and Child Psychiatry)
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Abstract

Narcolepsy and psychiatric disorders have a significant but unrecognized relationship, which is an area of evolving interest, but unfortunately, the association is poorly understood. It is not uncommon for the two to occur co-morbidly. However, narcolepsy is frequently misdiagnosed initially as a psychiatric condition, contributing to the protracted time to accurate diagnosis and treatment. Narcolepsy is a disabling neurodegenerative condition that carries a high risk for development of social and occupational dysfunction. Deterioration in function may lead to the secondary development of psychiatric symptoms. Inversely, the development of psychiatric symptoms can lead to the deterioration in function and quality of life. The overlap in pharmaceutical intervention may further enhance the difficulty to distinguish between diagnoses. Comprehensive care for patients with narcolepsy should include surveillance for psychiatric illness and appropriate treatment when necessary. Further research is necessary to better understand the underlying pathophysiology between psychiatric disease and narcolepsy. View Full-Text
Keywords: narcolepsy; schizophrenia; attention deficit hyperactivity disorder; depression; anxiety; psychiatric disorders narcolepsy; schizophrenia; attention deficit hyperactivity disorder; depression; anxiety; psychiatric disorders
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Morse, A.M.; Sanjeev, K. Narcolepsy and Psychiatric Disorders: Comorbidities or Shared Pathophysiology? Med. Sci. 2018, 6, 16.

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