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Open AccessArticle

Identification of the Ovine Keratin-Associated Protein 21-1 Gene and Its Association with Variation in Wool Traits

by 1,2,†, 1,2,3, 1,2,3, 1,†, 1,2, 1,2, 1,2, 1,2,* and 1,2,3,*
1
Gansu Key Laboratory of Herbivorous Animal Biotechnology, Faculty of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China
2
International Wool Research Institute, Gansu Agricultural University, Lanzhou 730070, China
3
Gene-Marker Laboratory, Faculty of Agricultural and Life Sciences, Lincoln University, Lincoln 7647, New Zealand
*
Authors to whom correspondence should be addressed.
Authors equally contributed to this work.
Animals 2019, 9(7), 450; https://doi.org/10.3390/ani9070450
Received: 27 May 2019 / Revised: 8 July 2019 / Accepted: 12 July 2019 / Published: 16 July 2019
(This article belongs to the Collection Applications of Quantitative Genetics in Livestock Production)
Keratin-associated proteins (KAPs) are key constituents of wool and hair fibers. In this study, the ovine keratin-associated protein 21-1 gene (KRTAP21-1) was identified, and association analysis showed that its variation affected wool yield, which prompted the conclusion that the gene may have potential use as a genetic maker for improving wool yield.
Keratin-associated proteins (KAPs) are key constituents of wool and hair fibers. In this study, an ovine KAP gene encoding a HGT-KAP protein was identified. The gene was different from all of the HGT-KAP genes identified in sheep, but was closely related to the human KAP21-1 gene, suggesting that it represented the unidentified ovine KRTAP21-1. Four variants (named A to D) of ovine KRTAP21-1 were found in 360 Merino × Southdown-cross lambs from four sire lines. Three sequence variations were detected among these variants. Two of the sequence variations were located upstream of the coding region and the remaining one was a synonymous variation in the coding sequence. Six genotypes were found in the Merino-cross lambs, with only two of the genotypes (AA and AC) occurring at a frequency of over 5%. Wool from sheep of genotype AA had a higher yield than that from AC sheep (p = 0.014), but tended to have a lower greasy fleece weight (GFW) than that of genotype AC (P = 0.078). This suggests that variation in KRTAP21-1 affects wool yield and the gene may have potential for use as a genetic maker for improving wool yield. View Full-Text
Keywords: KAP21-1 gene (KRTAP21-1); variation; wool yield; sheep KAP21-1 gene (KRTAP21-1); variation; wool yield; sheep
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MDPI and ACS Style

Li, S.; Zhou, H.; Gong, H.; Zhao, F.; Wang, J.; Liu, X.; Hu, J.; Luo, Y.; Hickford, J.G.H. Identification of the Ovine Keratin-Associated Protein 21-1 Gene and Its Association with Variation in Wool Traits. Animals 2019, 9, 450. https://doi.org/10.3390/ani9070450

AMA Style

Li S, Zhou H, Gong H, Zhao F, Wang J, Liu X, Hu J, Luo Y, Hickford JGH. Identification of the Ovine Keratin-Associated Protein 21-1 Gene and Its Association with Variation in Wool Traits. Animals. 2019; 9(7):450. https://doi.org/10.3390/ani9070450

Chicago/Turabian Style

Li, Shaobin; Zhou, Huitong; Gong, Hua; Zhao, Fangfang; Wang, Jiqing; Liu, Xiu; Hu, Jiang; Luo, Yuzhu; Hickford, Jon G.H. 2019. "Identification of the Ovine Keratin-Associated Protein 21-1 Gene and Its Association with Variation in Wool Traits" Animals 9, no. 7: 450. https://doi.org/10.3390/ani9070450

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