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Plasmid-Mediated Colistin Resistance in Salmonella enterica: A Review

1
Faculty of Pharmacy, University of Coimbra, 3000-458 Coimbra, Portugal
2
Centre for Neuroscience and Cell Biology, University of Coimbra, 3004-517 Coimbra, Portugal
*
Author to whom correspondence should be addressed.
Microorganisms 2019, 7(2), 55; https://doi.org/10.3390/microorganisms7020055
Received: 31 January 2019 / Revised: 13 February 2019 / Accepted: 15 February 2019 / Published: 19 February 2019
(This article belongs to the Special Issue Multidrug-Resistant Pathogens)
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PDF [262 KB, uploaded 19 February 2019]

Abstract

Colistin is widely used in food-animal production. Salmonella enterica is a zoonotic pathogen, which can pass from animal to human microbiota through the consumption of contaminated food, and cause disease, often severe, especially in young children, elderly and immunocompromised individuals. Recently, plasmid-mediated colistin resistance was recognised; mcr-like genes are being identified worldwide. Colistin is not an antibiotic used to treat Salmonella infections, but has been increasingly used as one of the last treatment options for carbapenem resistant Enterobacteria in human infections. The finding of mobilizable mcr-like genes became a global concern due to the possibility of horizontal transfer of the plasmid that often carry resistance determinants to beta-lactams and/or quinolones. An understanding of the origin and dissemination of mcr-like genes in zoonotic pathogens such as S. enterica will facilitate the management of colistin use and target interventions to prevent further spread. The main objective of this review was to collect epidemiological data about mobilized colistin resistance in S. enterica, describing the mcr variants, identified serovars, origin of the isolate, country and other resistance genes located in the same genetic platform. View Full-Text
Keywords: antimicrobial resistance; colistin; mcr; horizontal gene transfer; food safety; epidemiology antimicrobial resistance; colistin; mcr; horizontal gene transfer; food safety; epidemiology
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Lima, T.; Domingues, S.; Da Silva, G.J. Plasmid-Mediated Colistin Resistance in Salmonella enterica: A Review. Microorganisms 2019, 7, 55.

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